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 MOST VIEWED PAPERS | Cardiovascular Biology | calculated on 21 November 2008
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1
Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice.
Krohn R, Raffetseder U, …, Mertens PR, Weber C
Circulation 2007 Oct 16 116(16):1812-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Harrison with Klaudia Budzyn
Evaluated 20 May 2008
 
2
Recommended
F1000 Factor 3.0

New Finding
 Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure.
Watanabe T, Takeda T, …, Shirasawa T, Otsu K
J Am Coll Cardiol 2008 Aug 26 52(9):779-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Frenneaux with Julian O M Ormerod
Evaluated 12 Nov 2008
 
3
Must Read
F1000 Factor 6.4

Hypothesis
New Finding
Controversial
 The human ERG1 channel polymorphism, K897T, creates a phosphorylation site that inhibits channel activity.
Gentile S, Martin N, …, Erxleben C, Armstrong DL
Proc Natl Acad Sci U S A 2008 Sep 23 105(38):14704-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel / Hugues Abriel with Jean-Sébastien Rougier
First evaluation 25 Sep 2008 | Latest evaluation 18 Nov 2008
 
4
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.
Zhang X, Jin J, …, Ramgolam VS, Markovic-Plese S
J Immunol 2008 May 15 180(10):6988-96 [abstract on PubMed] [related articles] [order article]
Selected by | David Harrison with Meena Kumar
Evaluated 30 Sep 2008
 
5
Must Read
F1000 Factor 6.0

New Finding
Controversial
 Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.
Sale H, Wang J, …, Ackerman MJ, Robertson GA
Circ Res 2008 Sep 26 103(7):e81-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 5 Nov 2008
 
6
Recommended
F1000 Factor 3.0

Tech Advance
Novel Drug Target
 Modeling lymphangiogenesis in a three-dimensional culture system.
Bruyère F, Melen-Lamalle L, …, Foidart JM, Noël A
Nat Methods 2008 May 5(5):431-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Bates with Andrew V. Benest
Evaluated 24 Sep 2008
 
7
Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Formation of human myocardium in the rat heart from human embryonic stem cells.
Laflamme MA, Gold J, …, Muskheli V, Murry CE
Am J Pathol 2005 Sep 167(3):663-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Giulio Gabbiani
Evaluated 7 Sep 2005
 
8
Must Read
F1000 Factor 6.4

New Finding
 Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.
Kerkelä R, Grazette L, …, Durand JB, Force T
Nat Med 2006 Aug 12(8):908-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Kyriakis / Susan Steinberg
First evaluation 1 Aug 2006 | Latest evaluation 20 Nov 2007

 
9
Exceptional
F1000 Factor 10.7

Hypothesis
New Finding
Tech Advance
Controversial
 Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Crowley SD, Gurley SB, …, Le TH, Coffman TM
Proc Natl Acad Sci U S A 2006 Nov 21 103(47):17985-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthew Breyer / Soeren Sheikh / Raymond Harris / Anna Dominiczak / Tom Lohmeier / David J Webb / Robert Carey
First evaluation 17 Nov 2006 | Latest evaluation 25 Jul 2007

 
10
Exceptional
F1000 Factor 9.9

Hypothesis
New Finding
Novel Drug Target
 Control of stress-dependent cardiac growth and gene expression by a microRNA.
van Rooij E, Sutherland LB, …, Hill J, Olson EN
Science 2007 Apr 27 316(5824):575-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hugues Abriel / Hans van Beek / Aniko Naray-Fejes-Toth
First evaluation 27 Mar 2007 | Latest evaluation 11 May 2007

Most Viewed lists are generated every day and reflect use of F1000 Biology over the preceding 14 day period.

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