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Drug Discovery & Design


 MOST VIEWED PAPERS | Chemical Biology | calculated on 8 January 2009
 browse faculty | show Most Viewed Papers in

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1
Exceptional
F1000 Factor 9.8

Tech Advance
 Real-time DNA sequencing from single polymerase molecules.
Eid J, Fehr A, …, Korlach J, Turner S
Science 2009 Jan 2 323(5910):133-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michal Lebl / Fritz Eckstein / Aldons J Lusis
First evaluation 1 Dec 2008 | Latest evaluation 8 Jan 2009
 
2
Must Read
F1000 Factor 6.4

Hypothesis
New Finding
Tech Advance
Novel Drug Target
 PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
Singh R, Manjunatha U, …, Jiricek J, Barry CE
Science 2008 Nov 28 322(5906):1392-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barry Stoddard / Ken Wilson
First evaluation 2 Jan 2009 | Latest evaluation 9 Jan 2009
 
3
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure.
Komander D, Garg R, …, Ridley AJ, Barford D
EMBO J 2008 Dec 3 27(23):3175-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthias Buck
Evaluated 5 Jan 2009
 
4
Recommended
F1000 Factor 3.0

Tech Advance
 Nanoscale imaging of molecular positions and anisotropies.
Gould TJ, Gunewardene MS, …, Gosse JA, Hess ST
Nat Methods 2008 Dec 5(12):1027-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S. Licht
Evaluated 5 Jan 2009
 
5
Exceptional
F1000 Factor 12.3

New Finding
Tech Advance
 Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system.
Livet J, Weissman TA, …, Sanes JR, Lichtman JW
Nature 2007 Nov 1 450(7166):56-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kees Jalink / Alain Ghysen / Jonathan Sweedler / Liqun Luo / Catherine Krull / Markus Ruegg / Stanley Appel / David P. Wolfer / Andy Groves / Bruce Cumming / Guoping Feng / Edvard I. Moser / Etienne Joly / Martine Roussel
First evaluation 8 Nov 2007 | Latest evaluation 22 Jan 2008
 
6
Recommended
F1000 Factor 3.0

Tech Advance
 Tuning a three-component reaction for trapping kinase substrate complexes.
Statsuk AV, Maly DJ, …, Kuriyan J, Shokat KM
J Am Chem Soc 2008 Dec 24 130(51):17568-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hening Lin
Evaluated 2 Jan 2009
 
7
Must Read
F1000 Factor 6.0

New Finding
 Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases.
O'Maille PE, Malone A, …, Manning G, Noel JP
Nat Chem Biol 2008 Oct 4(10):617-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frances Arnold with Cara Tracewell
Evaluated 2 Jan 2009
 
8
Exceptional
F1000 Factor 12.8

Hypothesis
New Finding
 Control of gene expression by a natural metabolite-responsive ribozyme.
Winkler WC, Nahvi A, …, Collins JA, Breaker RR
Nature 2004 Mar 18 428(6980):281-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David M.J. Lilley / Richard Maraia / Samuel Butcher / Eric Westhof / Peter Unrau / Scott K. Silverman / Fritz Eckstein / Burckhard Seelig / Andrew D. Sharrocks / Janet Morrow / Andres Jaschke / John Burke / Reinhard Luehrmann
First evaluation 18 Mar 2004 | Latest evaluation 17 May 2004
 
9
Must Read
F1000 Factor 6.4

New Finding
Tech Advance
Novel Drug Target
 Chemical control of protein stability and function in living mice.
Banaszynski LA, Sellmyer MA, …, Wandless TJ, Thorne SH
Nat Med 2008 Oct 14(10):1123-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine with Yongqiang Feng / Thomas W. von Geldern
First evaluation 20 Nov 2008 | Latest evaluation 21 Nov 2008
 
10
Exceptional
F1000 Factor 9.0

New Finding
Refutation
Novel Drug Target
 Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.
Boshoff HI, Xu X, …, Williams KJ, Barry CE
J Biol Chem 2008 Jul 11 283(28):19329-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Squire Booker
Evaluated 27 Oct 2008

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