Faculty of 1000 Biology | Most-viewed Top 10

1-Dec-2008

Top 10s

Molecular Biology

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Control of Gene Expression

Nuclear Structure & Function

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	Exceptional
F1000 Factor 10.4

Hypothesis

New Finding

Species-specific transcription in mice carrying human chromosome 21.
Wilson MD, Barbosa-Morais NL, …, Tavaré S, Odom DT
Science 2008 Oct 17 322(5900):434-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Yoav Gilad / Kenneth Zaret / Deyou Zheng / Julin Maloof with Jose M. Jimenez-Gomez / Lin Chen with Reza Kalhor / Tom Misteli with Evi Soutoglou

First evaluation 13 Oct 2008 | Latest evaluation 24 Nov 2008

	Recommended
F1000 Factor 3.0

New Finding

A small molecule enhances RNA interference and promotes microRNA processing.
Shan G, Li Y, …, He C, Jin P
Nat Biotechnol 2008 Aug 26(8):933-40 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Gabriele Varani
Evaluated 14 Nov 2008

	Must Read
F1000 Factor 6.0

Hypothesis

New Finding

Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs.
Hirota K, Miyoshi T, …, Shibata T, Ohta K
Nature 2008 Nov 6 456(7218):130-4 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Daniel Reines
Evaluated 18 Nov 2008

	Must Read
F1000 Factor 6.6

Hypothesis

New Finding

HARP is an ATP-driven annealing helicase.
Yusufzai T, Kadonaga JT
Science 2008 Oct 31 322(5902):748-50 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Botchan / Lucio Comai / Jessica Downs
First evaluation 13 Nov 2008 | Latest evaluation 17 Nov 2008

	Recommended
F1000 Factor 3.0

New Finding

Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.
Brown JM, Green J, …, Iborra FJ, Buckle VJ
J Cell Biol 2008 Sep 22 182(6):1083-97 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Peter Shaw
Evaluated 18 Nov 2008

	Recommended
F1000 Factor 3.2

New Finding

Tech Advance

Novel Drug Target

Engineering microRNA responsiveness to decrease virus pathogenicity.
Kelly EJ, Hadac EM, Greiner S, Russell SJ
Nat Med 2008 Nov 14(11):1278-83 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | James Crowe / Lynne Maquat with Olaf Isken
First evaluation 12 Nov 2008 | Latest evaluation 19 Nov 2008

	Exceptional
F1000 Factor 9.8

Hypothesis

New Finding

Novel Drug Target

Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis.
Pearce MJ, Mintseris J, …, Gygi SP, Darwin KH
Science 2008 Oct 2 [abstract on PubMed] [related articles] [full text]

Selected by | Virginia Miller / Tom Rapoport with Ann Marie Stanley / Zhen-Qiang Pan with Antonio Sarikas
First evaluation 16 Oct 2008 | Latest evaluation 6 Nov 2008

	Recommended
F1000 Factor 3.2

Hypothesis

New Finding

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation.
Tay Y, Zhang J, …, Lim B, Rigoutsos I
Nature 2008 Oct 23 455(7216):1124-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Yi Eve Sun with Weihong Ge

/ Peter Sarnow with Cara Pager

First evaluation 25 Nov 2008 | Latest evaluation 27 Nov 2008

	Recommended
F1000 Factor 3.0

New Finding

Controversial

Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase.
Nagai S, Dubrana K, …, Gasser SM, Krogan NJ
Science 2008 Oct 24 322(5901):597-602 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Steven Brill
Evaluated 12 Nov 2008

	Recommended
F1000 Factor 3.0

New Finding

The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.
Sheaffer KL, Updike DL, Mango SE
Curr Biol 2008 Sep 23 18(18):1355-64 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Christopher Proud
Evaluated 12 Nov 2008

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