Faculty of 1000 Biology | Most-viewed Top 10

21-Nov-2008

Top 10s

Biotechnology

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Agriculture & Biotechnology

Applied Microbiology

Biocatalysis

Chemical Biology of the Cell

Drug Discovery & Design

Environmental Microbiology

Genomics

Medical Genetics

Pharmacogenomics

Protein Chemistry & Proteomics

Small Molecule Chemistry

Structural Genomics

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	Must Read
F1000 Factor 6.5

New Finding

Tech Advance

Global protein stability profiling in mammalian cells.
Yen HC, Xu Q, …, Zhao Z, Elledge SJ
Science 2008 Nov 7 322(5903):918-23 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Berl R. Oakley / Hunter Fraser

/ Michael Lenhard

First evaluation 12 Nov 2008 | Latest evaluation 20 Nov 2008

	Exceptional
F1000 Factor 10.1

Hypothesis

New Finding

Species-specific transcription in mice carrying human chromosome 21.
Wilson MD, Barbosa-Morais NL, …, Tavaré S, Odom DT
Science 2008 Oct 17 322(5900):434-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Yoav Gilad / Kenneth Zaret / Deyou Zheng / Julin Maloof with Jose M. Jimenez-Gomez / Lin Chen with Reza Kalhor

First evaluation 13 Oct 2008 | Latest evaluation 14 Nov 2008

	Recommended
F1000 Factor 3.0

Tech Advance

Real-time imaging of the intracellular glutathione redox potential.
Gutscher M, Pauleau AL, …, Meyer AJ, Dick TP
Nat Methods 2008 Jun 5(6):553-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Ruma Banerjee
Evaluated 5 Nov 2008

	Must Read
F1000 Factor 6.0

Hypothesis

New Finding

Root-secreted malic Acid recruits beneficial soil bacteria.
Rudrappa T, Czymmek KJ, Paré PW, Bais HP
Plant Physiol 2008 Nov 148(3):1547-56 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Venkatesan Sundaresan
Evaluated 10 Nov 2008

	Exceptional
F1000 Factor 9.0

Tech Advance

Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules.
Hodis E, Prilusky J, …, Moult J, Sussman JL
Genome Biol 2008 Aug 3 9(8):R121 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Burkhard Rost
Evaluated 29 Oct 2008

	Exceptional
F1000 Factor 14.5

Hypothesis

New Finding

Controversial

Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis.
Lolle SJ, Victor JL, Young JM, Pruitt RE
Nature 2005 Mar 24 434(7032):505-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Frank Lyko / Shigeru Iida / Kay Schneitz / Judy Wall / Marjori Matzke / James Carrington / Jose Luis Riechmann / Christian Hardtke / John Bowman / James Hu / Caren Chang / Venkatesan Sundaresan / Philip Benfey / Stephan Beck / Magnus Nordborg / Neelima Sinha / Martin Parniske / Elena Alvarez-Buylla / Elizabeth Kellogg / Elizabeth Hood
Dissenters | Alejandro Sanchez-Alvarado
First evaluation 24 Mar 2005 | Latest evaluation 24 May 2005

	Must Read
F1000 Factor 6.0

Confirmation

Tech Advance

Novel Drug Target

Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells.
Fujikawa Y, Urano Y, …, Inoue H, Nagano T
J Am Chem Soc 2008 Nov 5 130(44):14533-43 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Hening Lin

Evaluated 17 Nov 2008

	Must Read
F1000 Factor 6.0

Hypothesis

New Finding

Novel Drug Target

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.
Chen CH, Budas GR, …, Hurley TD, Mochly-Rosen D
Science 2008 Sep 12 321(5895):1493-5 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | David Triggle
Evaluated 11 Nov 2008

	Exceptional
F1000 Factor 12.3

New Finding

Tech Advance

Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system.
Livet J, Weissman TA, …, Sanes JR, Lichtman JW
Nature 2007 Nov 1 450(7166):56-62 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Kees Jalink / Alain Ghysen / Jonathan Sweedler / Liqun Luo / Catherine Krull / Markus Ruegg / Stanley Appel / David P. Wolfer / Andy Groves / Bruce Cumming / Guoping Feng / Edvard I. Moser / Etienne Joly / Martine Roussel
First evaluation 8 Nov 2007 | Latest evaluation 22 Jan 2008

	Recommended
F1000 Factor 3.0

Confirmation

Tech Advance

Systematic assessment of copy number variant detection via genome-wide SNP genotyping.
Cooper GM, Zerr T, …, Eichler EE, Nickerson DA
Nat Genet 2008 Oct 40(10):1199-203 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Yasushi Okazaki
Evaluated 4 Nov 2008

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