Faculty of 1000 Biology | Current Top 10

28-Aug-2008

Top 10s

ALL OF BIOLOGY

Current Top 10

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	Exceptional
F1000 Factor 10.1

Hypothesis

New Finding

Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection.
Premenko-Lanier M, Moseley NB, …, Romagnoli PA, Altman JD
Nature 2008 Aug 14 454(7206):894-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | David Leib / Barry Rouse / Michael McChesney / Marcia Blackman

First evaluation 18 Aug 2008 | Latest evaluation 27 Aug 2008

	Exceptional
F1000 Factor 9.6

New Finding

Controversial

Dichotomous dopaminergic control of striatal synaptic plasticity.
Shen W, Flajolet M, Greengard P, Surmeier DJ
Science 2008 Aug 8 321(5890):848-51 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Xiao-Jing Wang / Michael Frank
Evaluated 19 Aug 2008

	Exceptional
F1000 Factor 8.4

Confirmation

Hypothesis

New Finding

Controversial

Novel Drug Target

AMPK and PPARdelta agonists are exercise mimetics.
Narkar VA, Downes M, …, Shaw RJ, Evans RM
Cell 2008 Aug 8 134(3):405-15 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Anthony Means / James Timmons / Fredric Wondisford / Markus Ruegg

First evaluation 12 Aug 2008 | Latest evaluation 21 Aug 2008

	Exceptional
F1000 Factor 8.4

Hypothesis

New Finding

Tech Advance

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.
Gascoigne KE, Taylor SS
Cancer Cell 2008 Aug 12 14(2):111-22 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Duane Compton / Michael Weber / Claire Walczak / Surender Kharbanda
First evaluation 31 Jul 2008 | Latest evaluation 20 Aug 2008

	Exceptional
F1000 Factor 8.1

Hypothesis

New Finding

A mechanism for asymmetric segregation of age during yeast budding.
Shcheprova Z, Baldi S, …, Gonnet G, Barral Y
Nature 2008 Aug 7 454(7205):728-34 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Yukiko Yamashita / Thomas Nystrom / Audrey Gasch

First evaluation 7 Aug 2008 | Latest evaluation 22 Aug 2008

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.
Wei Y, Pattingre S, …, Bassik M, Levine B
Mol Cell 2008 Jun 20 30(6):678-88 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | David C Rubinsztein / Vojo Deretic

First evaluation 8 Aug 2008 | Latest evaluation 27 Aug 2008

	Exceptional
F1000 Factor 8.0

Confirmation

Hypothesis

New Finding

Hippocampus-independent phase precession in entorhinal grid cells.
Hafting T, Fyhn M, …, Moser MB, Moser EI
Nature 2008 Jun 26 453(7199):1248-52 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Mayank Mehta / Neil Burgess
First evaluation 30 Jul 2008 | Latest evaluation 18 Aug 2008

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Novel Drug Target

An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans.
Budovskaya YV, Wu K, …, Johnson TE, Kim SK
Cell 2008 Jul 25 134(2):291-303 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Nektarios Tavernarakis / Susan Mango
First evaluation 12 Aug 2008 | Latest evaluation 13 Aug 2008

	Must Read
F1000 Factor 6.5

Hypothesis

New Finding

Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair.
Chen CC, Carson JJ, …, Linger J, Tyler JK
Cell 2008 Jul 25 134(2):231-43 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | James Bone / Keith Caldecott / John Rouse

First evaluation 5 Aug 2008 | Latest evaluation 22 Aug 2008

	Must Read
F1000 Factor 6.4

Hypothesis

New Finding

Tech Advance

Local dendritic activity sets release probability at hippocampal synapses.
Branco T, Staras K, Darcy KJ, Goda Y
Neuron 2008 Aug 14 59(3):475-85 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Venkatesh Murthy / Michael Ehlers

First evaluation 19 Aug 2008 | Latest evaluation 27 Aug 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.