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Antimicrobial Agents
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Bioinformatics
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 HIDDEN JEWELS | Pharmacology & Drug Discovery | calculated on 8 January 2009
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1
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure.
Komander D, Garg R, …, Ridley AJ, Barford D
EMBO J 2008 Dec 3 27(23):3175-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthias Buck
Evaluated 5 Jan 2009
 
2
Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice.
Krohn R, Raffetseder U, …, Mertens PR, Weber C
Circulation 2007 Oct 16 116(16):1812-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Harrison with Klaudia Budzyn
Evaluated 20 May 2008
 
3
Exceptional
F1000 Factor 9.0

New Finding
Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway.
Zhang Q, Hong M, …, Ma J, You G
J Biol Chem 2008 Nov 21 283(47):32570-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lawrence Lash
Evaluated 2 Jan 2009
 
4
Recommended
F1000 Factor 3.0

New Finding
The prolonged life-span of alveolar macrophages.
Murphy J, Summer R, …, Kotton DN, Fine A
Am J Respir Cell Mol Biol 2008 Apr 38(4):380-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthias Ochs with Christian Mühlfeld
Evaluated 22 Dec 2008
 
5
Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction.
Flagel SB, Akil H, Robinson TE
Neuropharmacology 2008 Jun 21 56 [abstract on PubMed] [related articles] [full text]
Selected by | Norman White
Evaluated 2 Jan 2009
 
6
Exceptional
F1000 Factor 9.0

New Finding
Safety and immunogenicity of RTS,S/AS02D malaria vaccine in infants.
Abdulla S, Oberholzer R, …, Ballou WR, Tanner M
N Engl J Med 2008 Dec 11 359(24):2533-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Murali Ramanathan
Evaluated 22 Dec 2008
 
7
Recommended
F1000 Factor 3.0

New Finding
Safety, Pharmacokinetics, and Antiretroviral Activity of Multiple Doses of Ibalizumab (formerly TNX-355), an Anti-CD4 Monoclonal Antibody, in HIV-1 Infected Adults.
Jacobson JM, Kuritzkes DR, …, Weinheimer SP, Lewis ST
Antimicrob Agents Chemother 2008 Nov 17 [abstract on PubMed] [related articles] [full text]
Selected by | Jonathan Schapiro
Evaluated 2 Dec 2008
 
8
Must Read
F1000 Factor 6.0

Hypothesis
Novel Drug Target
Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells.
Bourguignon LY, Peyrollier K, Xia W, Gilad E
J Biol Chem 2008 Jun 20 283(25):17635-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Gregg B. Fields
Evaluated 14 Jul 2008
 
9
Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
Cross-talk between G protein-coupled and epidermal growth factor receptors regulates gonadotropin-mediated steroidogenesis in Leydig cells.
Evaul K, Hammes SR
J Biol Chem 2008 Oct 10 283(41):27525-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Baranski
Evaluated 7 Jan 2009
 
10
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.
Zhang X, Jin J, …, Ramgolam VS, Markovic-Plese S
J Immunol 2008 May 15 180(10):6988-96 [abstract on PubMed] [related articles] [order article]
Selected by | David Harrison with Meena Kumar
Evaluated 30 Sep 2008

Hidden Jewels Top 10 lists are generated every day and comprise only papers published in less widely read journals (the grouping of which is the same for all Faculties; therefore, whilst some of these journals may be considered 'high profile' in their immediate Faculty, they are included in the Hidden Jewels lists because they probably will not be so obvious to people outside that specific Faculty). The Hidden Jewels list of papers is ordered by the number of times a paper's evaluation(s) has been viewed over the past 14 days.


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