Faculty of 1000 Biology | Current Top 10

5-Jul-2008

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1

	Exceptional
F1000 Factor 10.3

Confirmation

Hypothesis

New Finding

Tech Advance

Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution.
Lange OF, Lakomek NA, …, Griesinger C, de Groot BL
Science 2008 Jun 13 320(5882):1471-5 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Matthias Buck / Gottfried Otting / Antonio Rosato / Torleif Härd

/ Moosa Mohammadi

First evaluation 16 Jun 2008 | Latest evaluation 3 Jul 2008

2

	Exceptional
F1000 Factor 9.6

Confirmation

New Finding

Tech Advance

Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.
Chen Z, Yang H, Pavletich NP
Nature 2008 May 22 453(7194):489-4 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Edward Egelman / Donald Rio

First evaluation 3 Jun 2008 | Latest evaluation 1 Jul 2008

3

	Exceptional
F1000 Factor 8.0

New Finding

The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors.
Tsuda H, Han SM, …, Miller MA, Bellen HJ
Cell 2008 Jun 13 133(6):963-77 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Andrew Chisholm / Antonella De Matteis

First evaluation 17 Jun 2008 | Latest evaluation 4 Jul 2008

4

	Exceptional
F1000 Factor 8.0

New Finding

Tech Advance

A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals.
Lin MZ, Glenn JS, Tsien RY
Proc Natl Acad Sci U S A 2008 Jun 3 105(22):7744-9 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Hening Lin with Xiaoyang Su / Sanford Simon

First evaluation 10 Jun 2008 | Latest evaluation 3 Jul 2008

5

	Must Read
F1000 Factor 6.6

Hypothesis

New Finding

Novel Drug Target

A microbial symbiosis factor prevents intestinal inflammatory disease.
Mazmanian SK, Round JL, Kasper DL
Nature 2008 May 29 453(7195):620-5 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Victor Nizet / Christopher Thanos / Richard Grencis

First evaluation 9 Jun 2008 | Latest evaluation 1 Jul 2008

6

	Must Read
F1000 Factor 6.5

Hypothesis

New Finding

XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
Fan L, Fuss JO, …, Cooper PK, Tainer JA
Cell 2008 May 30 133(5):789-800 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Errol C. Friedberg / Katsu Murakami / Alan Lehmann

First evaluation 18 Jun 2008 | Latest evaluation 2 Jul 2008

7

	Must Read
F1000 Factor 6.4

Confirmation

Hypothesis

New Finding

A phosphatase cascade by which rewarding stimuli control nucleosomal response.
Stipanovich A, Valjent E, …, Hervé D, Girault JA
Nature 2008 Jun 12 453(7197):879-84 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Johannes Hell

/ Kent Berridge

First evaluation 1 Jul 2008 | Latest evaluation 3 Jul 2008

8

	Must Read
F1000 Factor 6.4

Hypothesis

New Finding

Tech Advance

Novel Drug Target

Activation of the cellular DNA damage response in the absence of DNA lesions.
Soutoglou E, Misteli T
Science 2008 Jun 13 320(5882):1507-10 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | John Lazo / Yosef Gruenbaum

First evaluation 12 Jun 2008 | Latest evaluation 2 Jul 2008

9

	Must Read
F1000 Factor 6.4

Hypothesis

New Finding

Mechanism of shape determination in motile cells.
Keren K, Pincus Z, …, Mogilner A, Theriot JA
Nature 2008 May 22 453(7194):475-80 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Ken Jacobson / Steven Altschuler
First evaluation 18 Jun 2008 | Latest evaluation 25 Jun 2008

10

	Must Read
F1000 Factor 6.4

Hypothesis

New Finding

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils.
Heit B, Robbins SM, …, Jirik FR, Kubes P
Nat Immunol 2008 Jul 9(7):743-52 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Marcus Thelen / Anna Huttenlocher
First evaluation 23 Jun 2008 | Latest evaluation 24 Jun 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.

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