Faculty of 1000 Biology | All Time Top 10

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Renal Biology

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All Time Top 10

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Renal Pharmacology

Renal, Fluid & Electrolyte Physiology

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	Exceptional
F1000 Factor 10.7

Hypothesis

New Finding

Tech Advance

Controversial

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Crowley SD, Gurley SB, …, Le TH, Coffman TM
Proc Natl Acad Sci U S A 2006 Nov 21 103(47):17985-90 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Matthew Breyer / Soeren Sheikh / Raymond Harris / Anna Dominiczak / Tom Lohmeier / David J Webb / Robert Carey
First evaluation 17 Nov 2006 | Latest evaluation 25 Jul 2007

	Exceptional
F1000 Factor 8.0

New Finding

Novel Drug Target

The Notch pathway in podocytes plays a role in the development of glomerular disease.
Niranjan T, Bielesz B, …, Thomas DB, Susztak K
Nat Med 2008 Mar 14(3):290-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Matthew Breyer / Moshe Levi
First evaluation 27 Mar 2008 | Latest evaluation 12 Jun 2008

	Exceptional
F1000 Factor 8.0

New Finding

Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia.
Nijenhuis T, Vallon V, …, Hoenderop JG, Bindels RJ
J Clin Invest 2005 Jun 115(6):1651-8 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Jens Leipziger / Gerardo Gamba
First evaluation 16 Jun 2005 | Latest evaluation 17 Jun 2005

	Must Read
F1000 Factor 6.4

Hypothesis

New Finding

Adiponectin regulates albuminuria and podocyte function in mice.
Sharma K, Ramachandrarao S, …, Falkner B, Goldstein BJ
J Clin Invest 2008 May 118(5):1645-56 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Norma A. Bobadilla / Christos Chatziantoniou with Christos Chadjichristos
First evaluation 19 May 2008 | Latest evaluation 27 Jun 2008

	Must Read
F1000 Factor 6.4

New Finding

The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6.
Grünberger C, Obermayer B, …, Kurtz A, Schweda F
Circ Res 2006 Nov 24 99(11):1197-206 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Janos Peti-Peterdi / Heimo Ehmke
First evaluation 8 Jan 2007 | Latest evaluation 4 Jun 2007

	Must Read
F1000 Factor 6.4

New Finding

Decreased intracellular calcium stimulates renin release via calcium-inhibitable adenylyl cyclase.
Ortiz-Capisano MC, Ortiz PA, …, Garvin JL, Beierwaltes WH
Hypertension 2007 Jan 49(1):162-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Janos Peti-Peterdi / Heimo Ehmke
First evaluation 8 Jan 2007 | Latest evaluation 4 Jun 2007

	Recommended
F1000 Factor 3.2

Confirmation

Tech Advance

Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na,K,2Cl co-transporter.
Oppermann M, Mizel D, …, Schnermann J, Castrop H
J Am Soc Nephrol 2006 Aug 17(8):2143-52 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Janos Peti-Peterdi / Gerardo Gamba
First evaluation 1 Aug 2006 | Latest evaluation 8 Sep 2006

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.