Faculty of 1000 Biology | All Time Top 10 > Metabolic & Endocrine Science

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Metabolic & Endocrine Science

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All Time Top 10

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Endocrine & Metabolic Pharmacology

Endocrinology

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	Exceptional
F1000 Factor 8.2

Hypothesis

New Finding

Evolution of hormone-receptor complexity by molecular exploitation.
Bridgham JT, Carroll SM, Thornton JW
Science 2006 Apr 7 312(5770):97-101 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Richard Lenski / Aniko Naray-Fejes-Toth / Paul Webb
Dissenters | John Funder
Author Response | Joseph Thornton
First evaluation 11 Apr 2006 | Latest evaluation 15 May 2006

	Exceptional
F1000 Factor 8.0

Confirmation

Hypothesis

New Finding

Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions.
Grossmann C, Benesic A, …, Gassner B, Gekle M
Mol Endocrinol 2005 Jul 19(7):1697-710 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Elise Gomez-Sanchez / Morag Young
First evaluation 10 Aug 2005 | Latest evaluation 21 Sep 2005

	Must Read
F1000 Factor 6.4

Confirmation

Hypothesis

New Finding

Controversial

Novel Drug Target

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.
Cao H, Gerhold K, …, Watkins SM, Hotamisligil GS
Cell 2008 Sep 19 134(6):933-44 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Henry Ginsberg / Amira Klip with Jonathan D Schertzer
First evaluation 28 Oct 2008 | Latest evaluation 26 Nov 2008

	Must Read
F1000 Factor 6.4

Confirmation

Hypothesis

New Finding

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
Bujalska IJ, Draper N, …, Walker EA, Stewart PM
J Mol Endocrinol 2005 Jun 34(3):675-84 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Morag Young / Elise Gomez-Sanchez
First evaluation 21 Sep 2005 | Latest evaluation 11 Jan 2006

	Must Read
F1000 Factor 4.9

Hypothesis

New Finding

Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.
Morioka T, Asilmaz E, …, Kennedy RT, Kulkarni RN
J Clin Invest 2007 Oct 117(10):2860-8 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Mark Atkinson / Carolyn Ecelbarger / Raghavendra Mirmira
First evaluation 12 Oct 2007 | Latest evaluation 29 Nov 2007

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

Novel Drug Target

The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages.
Hall JM, McDonnell DP
Mol Endocrinol 2007 Aug 21(8):1756-68 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Aniko Naray-Fejes-Toth / Paul Webb
First evaluation 26 Nov 2007 | Latest evaluation 11 Mar 2008

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.