Faculty of 1000 Biology | All Time Top 10

21-Nov-2008

Top 10s

Immunology

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Allergy & Hypersensitivity

Antigen Processing & Recognition

Autoimmunity

Genetics of the Immune System

Immune Response

Immunity to Infections

Immunomodulation

Innate Immunity

Leukocyte Activation

Leukocyte Development

Leukocyte Signalling & Gene Expression

Related Sections

Cellular Microbiology & Pathogenesis

Immunopharmacology & Hematologic Pharmacology

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	Exceptional
F1000 Factor 12.4

Hypothesis

New Finding

Asymmetric T lymphocyte division in the initiation of adaptive immune responses.
Chang JT, Palanivel VR, …, Weninger W, Reiner SL
Science 2007 Mar 23 315(5819):1687-91 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | George Yap / Toshinori Nakayama / Richard Locksley / Etienne Joly / Torben Lund / Christian Engwerda / Stephen Doxsey / Clifford Harding / Leo Lefrancois / Shiv Pillai / Rong Li / Dale Umetsu / Michael Dustin / Francisco Sanchez-Madrid
First evaluation 14 Mar 2007 | Latest evaluation 3 Mar 2008

	Exceptional
F1000 Factor 12.3

New Finding

Tech Advance

Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system.
Livet J, Weissman TA, …, Sanes JR, Lichtman JW
Nature 2007 Nov 1 450(7166):56-62 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Kees Jalink / Alain Ghysen / Jonathan Sweedler / Liqun Luo / Catherine Krull / Markus Ruegg / Stanley Appel / David P. Wolfer / Andy Groves / Bruce Cumming / Guoping Feng / Edvard I. Moser / Etienne Joly / Martine Roussel
First evaluation 8 Nov 2007 | Latest evaluation 22 Jan 2008

	Exceptional
F1000 Factor 12.1

Hypothesis

New Finding

Tech Advance

Restoring function in exhausted CD8 T cells during chronic viral infection.
Barber DL, Wherry EJ, …, Freeman GJ, Ahmed R
Nature 2006 Feb 9 439(7077):682-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Barry Rouse / Etienne Joly / Christian Engwerda / Nicholas Restifo / Allan Zajac / Linda Bradley / Jonathan Green / Lieping Chen / Luis J. Montaner / Arthur Hurwitz / Grant McFadden / Matthias von Herrath / Scott Gray-Owen
First evaluation 10 Jan 2006 | Latest evaluation 12 Jul 2006

	Exceptional
F1000 Factor 11.7

Hypothesis

New Finding

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.
Iijima M, Devreotes P
Cell 2002 May 31 109(5):599-610 [abstract on PubMed] [related articles] [order article]

Selected by | Silvia Arber / Silvio Gutkind / Steve Ward / Bruce Conklin / Phillip Hawkins / Jeffrey Axelrod / Henry R. Bourne / David Lambright / Anna Huttenlocher / Andreas Wodarz / Richard Gomer / Gerald Weeks
First evaluation 5 Jun 2002 | Latest evaluation 13 Aug 2002

	Exceptional
F1000 Factor 11.6

Hypothesis

New Finding

Tech Advance

Toll-dependent selection of microbial antigens for presentation by dendritic cells.
Blander JM, Medzhitov R
Nature 2006 Apr 6 440(7085):808-12 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Christopher Karp / Torben Lund / Peter Van Endert / Elizabeth Mellins / David Branch Moody / Dan Conrad / Laurence Eisenlohr / Etienne Joly / Marcus Thelen / Victor Nizet
First evaluation 6 Mar 2006 | Latest evaluation 13 Jun 2006

	Exceptional
F1000 Factor 11.4

Confirmation

Hypothesis

New Finding

Phagosomes are competent organelles for antigen cross-presentation.
Houde M, Bertholet S, …, Sacks D, Desjardins M
Nature 2003 Sep 25 425(6956):402-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Karin Romisch / Lutz Walter / Francisco Garcia-del Portillo / Caetano Reis e Sousa / Shiv Pillai / Frank Momburg / Stefan Kaufmann / Edward Collins / Paul Gleeson / Sergio Grinstein
First evaluation 7 Oct 2003 | Latest evaluation 19 Nov 2003

	Exceptional
F1000 Factor 11.4

Hypothesis

New Finding

Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages.
Gagnon E, Duclos S, …, Bergeron JJ, Desjardins M
Cell 2002 Jul 12 110(1):119-31 [abstract on PubMed] [related articles] [order article]

Selected by | Jonathan Howard / David Andrews / Stephane Meresse / Karin Romisch / Thomas Sollner / Matthew Albert / Joel Swanson / Sergio Grinstein / Christoph Borner / Anthony DeFranco
First evaluation 16 Jul 2002 | Latest evaluation 1 Oct 2002

	Exceptional
F1000 Factor 11.3

Hypothesis

New Finding

Novel Drug Target

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivanov II, McKenzie BS, …, Cua DJ, Littman DR
Cell 2006 Sep 22 126(6):1121-33 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Caetano Reis e Sousa / Christopher A. Hunter / Casey Weaver / Richard Williams / Dale Umetsu / Klaus Ley / Mercedes Rincon / Rachel Caspi / Fraydoon Rastinejad / Astar Winoto
First evaluation 2 Oct 2006 | Latest evaluation 2 Jan 2007

	Exceptional
F1000 Factor 11.2

Hypothesis

New Finding

Identification of a bacterial type III effector family with G protein mimicry functions.
Alto NM, Shao F, …, Boone C, Dixon JE
Cell 2006 Jan 13 124(1):133-45 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Sachdev Sidhu / Ariel Blocker / Ilan Rosenshine / Guy Tran Van Nhieu / Christoph Dehio / Michael Gold / Drusilla Burns / Pascale Cossart / Channing Der / Victor Nizet / Alfred Wittinghofer
First evaluation 13 Jan 2006 | Latest evaluation 27 Mar 2006

	Exceptional
F1000 Factor 11.2

Confirmation

Hypothesis

New Finding

ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells.
Guermonprez P, Saveanu L, …, Van Endert P, Amigorena S
Nature 2003 Sep 25 425(6956):397-402 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Colin Watts / Lutz Walter / Frank Momburg / Shiv Pillai / Francisco Garcia-del Portillo / Caetano Reis e Sousa / Judith Klumperman / Stefan Kaufmann / Sergio Grinstein
First evaluation 2 Oct 2003 | Latest evaluation 19 Nov 2003

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.