Faculty of 1000 Biology | All Time Top 10

21-Nov-2008

Top 10s

Molecular Medicine

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Antimicrobial Agents

Autoimmunity

Cancer Therapeutics

Cardiovascular Pharmacology

Cardiovascular Physiology/Circulation

Cell Growth & Division

Drug Discovery & Design

Endocrine & Metabolic Pharmacology

Endocrinology

Gastrointestinal Pharmacology

Gastrointestinal Physiology

Genito-Urinary & Reproductive Pharmacology

Immunomodulation

Immunopharmacology & Hematologic Pharmacology

Integrative Physiology

Medical Genetics

Medical Microbiology

Molecular Pharmacology

Muscle & Connective Tissue

Musculoskeletal & Dermatologic Pharmacology

Neural Homeostasis

Neurobiology of Disease & Regeneration

Neuropharmacology & Psychopharmacology

Pharmacogenomics

Pharmacokinetics & Drug Delivery

Physiogenomics

Renal, Fluid & Electrolyte Physiology

Reproductive Physiology

Respiratory physiology

Stem Cells & Regeneration

Toxicology

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	Exceptional
F1000 Factor 12.3

New Finding

Tech Advance

Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system.
Livet J, Weissman TA, …, Sanes JR, Lichtman JW
Nature 2007 Nov 1 450(7166):56-62 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Kees Jalink / Alain Ghysen / Jonathan Sweedler / Liqun Luo / Catherine Krull / Markus Ruegg / Stanley Appel / David P. Wolfer / Andy Groves / Bruce Cumming / Guoping Feng / Edvard I. Moser / Etienne Joly / Martine Roussel
First evaluation 8 Nov 2007 | Latest evaluation 22 Jan 2008

	Exceptional
F1000 Factor 12.1

Hypothesis

New Finding

Tech Advance

Restoring function in exhausted CD8 T cells during chronic viral infection.
Barber DL, Wherry EJ, …, Freeman GJ, Ahmed R
Nature 2006 Feb 9 439(7077):682-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Barry Rouse / Etienne Joly / Christian Engwerda / Nicholas Restifo / Allan Zajac / Linda Bradley / Jonathan Green / Lieping Chen / Luis J. Montaner / Arthur Hurwitz / Grant McFadden / Matthias von Herrath / Scott Gray-Owen
First evaluation 10 Jan 2006 | Latest evaluation 12 Jul 2006

	Exceptional
F1000 Factor 11.3

Hypothesis

New Finding

Novel Drug Target

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivanov II, McKenzie BS, …, Cua DJ, Littman DR
Cell 2006 Sep 22 126(6):1121-33 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Caetano Reis e Sousa / Christopher A. Hunter / Casey Weaver / Richard Williams / Dale Umetsu / Klaus Ley / Mercedes Rincon / Rachel Caspi / Fraydoon Rastinejad / Astar Winoto
First evaluation 2 Oct 2006 | Latest evaluation 2 Jan 2007

	Exceptional
F1000 Factor 11.1

Hypothesis

New Finding

Novel Drug Target

The inhibitory cytokine IL-35 contributes to regulatory T-cell function.
Collison LW, Workman CJ, …, Blumberg RS, Vignali DA
Nature 2007 Nov 22 450(7169):566-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Steve Ward / Grant Morahan / Thomas Nutman / Mark Smyth / Thomas Hunig / Barry Rouse / Anuradha Ray / Alan Landay / Rachel Caspi / Xiaojing Ma
First evaluation 28 Nov 2007 | Latest evaluation 3 Mar 2008

	Exceptional
F1000 Factor 11.1

Hypothesis

New Finding

Tech Advance

Matrix elasticity directs stem cell lineage specification.
Engler AJ, Sen S, Sweeney HL, Discher DE
Cell 2006 Aug 25 126(4):677-89 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Kenneth Yamada / Ray Rodgers / Carol Otey / Paul Bornstein / Avri Ben-Ze'ev / Michel Labouesse / Thomas Egelhoff / Deborah Andrew / Amy Wagers
First evaluation 30 Aug 2006 | Latest evaluation 3 Sep 2007

	Exceptional
F1000 Factor 10.8

Hypothesis

New Finding

Tech Advance

Transvascular delivery of small interfering RNA to the central nervous system.
Kumar P, Wu H, …, Shankar P, Manjunath N
Nature 2007 Jul 5 448(7149):39-43 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Richard Vile / Mark Kay / Angela Vincent / Marina Picciotto / Harukazu Nakamura / William H. Colledge / Günter Mayer / Michael Kiebler / Gerald Zamponi
First evaluation 3 Jul 2007 | Latest evaluation 11 Sep 2007

	Exceptional
F1000 Factor 10.8

Confirmation

Hypothesis

New Finding

Tech Advance

Controversial

An obesity-associated gut microbiome with increased capacity for energy harvest.
Turnbaugh PJ, Ley RE, …, Mardis ER, Gordon JI
Nature 2006 Dec 21 444(7122):1027-131 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | David Robertson / Joel Elmquist / Matthias Maiwald / Liang Tong / Joanna Goldberg / Marc Lecuit / Stefan Kaufmann / Joe Heitman / David Bilder
First evaluation 2 Jan 2007 | Latest evaluation 21 Feb 2007

	Exceptional
F1000 Factor 10.7

Hypothesis

New Finding

A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Kimchi-Sarfaty C, Oh JM, …, Ambudkar SV, Gottesman MM
Science 2007 Jan 26 315(5811):525-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | J. Steven Leeder / Michael Roth / Richard Maraia / Sue Malcolm / William Dalton / Paul Hollenberg / Tao Pan
First evaluation 30 Jan 2007 | Latest evaluation 19 Nov 2007

	Exceptional
F1000 Factor 10.7

Hypothesis

New Finding

Tech Advance

Controversial

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Crowley SD, Gurley SB, …, Le TH, Coffman TM
Proc Natl Acad Sci U S A 2006 Nov 21 103(47):17985-90 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Matthew Breyer / Soeren Sheikh / Raymond Harris / Anna Dominiczak / Tom Lohmeier / David J Webb / Robert Carey
First evaluation 17 Nov 2006 | Latest evaluation 25 Jul 2007

	Exceptional
F1000 Factor 10.7

Hypothesis

New Finding

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.
Nash P, Tang X, …, Pawson T, Tyers M
Nature 2001 Nov 29 414(6863):514-21 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Sara Courtneidge / Steven Reed / Jeffrey Wade Harper / John Stults / Angel Nebreda / Michael B. Yaffe / Andrius Kazlauskas / Joan Ruderman
First evaluation 12 Dec 2001 | Latest evaluation 18 Feb 2002

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.