Faculty of 1000 Biology | All Time Top 10

1-Dec-2008

Top 10s

Genomics & Genetics

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Animal Genetics

Bioinformatics

Evolutionary/Comparative Genetics

Genomics

Medical Genetics

Related Sections

Cell Growth & Division

Control of Gene Expression

Genetics of the Immune System

Microbial Evolution & Genomics

Nuclear Structure & Function

Pharmacogenomics

Physiogenomics

Plant Genetics & Gene Expression

Plant Genomes & Evolution

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	Exceptional
F1000 Factor 14.5

Hypothesis

New Finding

Controversial

Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis.
Lolle SJ, Victor JL, Young JM, Pruitt RE
Nature 2005 Mar 24 434(7032):505-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Frank Lyko / Shigeru Iida / Kay Schneitz / Judy Wall / Marjori Matzke / James Carrington / Jose Luis Riechmann / Christian Hardtke / John Bowman / James Hu / Caren Chang / Venkatesan Sundaresan / Philip Benfey / Stephan Beck / Magnus Nordborg / Neelima Sinha / Martin Parniske / Elena Alvarez-Buylla / Elizabeth Kellogg / Elizabeth Hood
Dissenters | Alejandro Sanchez-Alvarado
First evaluation 24 Mar 2005 | Latest evaluation 24 May 2005

	Exceptional
F1000 Factor 12.8

Hypothesis

New Finding

Control of gene expression by a natural metabolite-responsive ribozyme.
Winkler WC, Nahvi A, …, Collins JA, Breaker RR
Nature 2004 Mar 18 428(6980):281-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | David M.J. Lilley / Richard Maraia / Samuel Butcher / Eric Westhof / Peter Unrau / Scott K. Silverman / Fritz Eckstein / Burckhard Seelig / Andrew D. Sharrocks / Janet Morrow / Andres Jaschke / John Burke / Reinhard Luehrmann
First evaluation 18 Mar 2004 | Latest evaluation 17 May 2004

	Exceptional
F1000 Factor 12.4

Confirmation

New Finding

Tech Advance

Functional organization of the yeast proteome by systematic analysis of protein complexes.
Gavin AC, Bösche M, …, Neubauer G, Superti-Furga G
Nature 2002 Jan 10 415(6868):141-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Blatt / Kiyoshi Nagai / Sue Goo Rhee / Stephen Jackson / Steven Gygi / Guoping Feng / Mark Nelson / Rolf Apweiler / Marilyn Parsons / Miguel Penalva / Marie-Laure Yaspo / Ron Milligan / Michael Kiebler
First evaluation 18 Jan 2002 | Latest evaluation 24 Jul 2007

	Exceptional
F1000 Factor 11.7

Confirmation

Hypothesis

New Finding

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
Shi Y, Lan F, …, Casero RA, Shi Y
Cell 2004 Dec 29 119(7):941-53 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Steven Henikoff / Thomas Jenuwein / Chris Sander / Winship Herr / Dinah Singer / Robert Dutnall / Eric Selker / Frank Lyko / Daniel Reines / Benoit Coulombe / Robin Allshire
First evaluation 21 Dec 2004 | Latest evaluation 3 Feb 2005

	Exceptional
F1000 Factor 11.3

Confirmation

Hypothesis

New Finding

Tech Advance

Design of a novel globular protein fold with atomic-level accuracy.
Kuhlman B, Dantas G, …, Stoddard BL, Baker D
Science 2003 Nov 21 302(5649):1364-8 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Kristina Downing / Gideon Schreiber / Rob Russell / Wolfgang Guba / Nick Grishin / Padmanabhan Balaram / Robert Kelley / Kevin Plaxco / Sachdev Sidhu
First evaluation 28 Nov 2003 | Latest evaluation 3 Feb 2004

	Exceptional
F1000 Factor 11.2

Confirmation

Hypothesis

New Finding

Tech Advance

A genomic code for nucleosome positioning.
Segal E, Fondufe-Mittendorf Y, …, Wang JP, Widom J
Nature 2006 Aug 17 442(7104):772-8 [abstract on PubMed] [related articles] [order article]

Selected by | Brad Bernstein / Tom Misteli / Kerry Bloom / Nick Rhind / James Bone / Francesc Posas / Michael Meisterernst / Leonie Ringrose / Gabriele Varani
First evaluation 27 Jul 2006 | Latest evaluation 13 Dec 2006

	Exceptional
F1000 Factor 11.0

Hypothesis

New Finding

Tech Advance

An RNA gene expressed during cortical development evolved rapidly in humans.
Pollard KS, Salama SR, …, Vanderhaeghen P, Haussler D
Nature 2006 Sep 14 443(7108):167-72 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Kevan A. Martin / John Abrams / Deyou Zheng / Andrew Feinberg / Rafael Zardoya / Ali H. Brivanlou / Robert Sapolsky / Gabriele Varani / Christopher A. Walsh
First evaluation 22 Aug 2006 | Latest evaluation 15 Mar 2007

	Exceptional
F1000 Factor 11.0

New Finding

Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
Colosimo PF, Hosemann KE, …, Schluter D, Kingsley DM
Science 2005 Mar 25 307(5717):1928-33 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Detlef Weigel / Mohamed Noor / Patricia Simpson / Tony Long / Richard Harrison / Trudy Mackay / Molly Przeworski / Magnus Nordborg
First evaluation 6 Apr 2005 | Latest evaluation 16 Jun 2005

	Exceptional
F1000 Factor 11.0

Hypothesis

New Finding

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi.
Volpe TA, Kidner C, …, Grewal SI, Martienssen RA
Science 2002 Sep 13 297(5588):1833-7 [abstract on PubMed] [related articles] [FREE full text]

Selected by | L. Alison McInnes / Robin Allshire / Rivka Dikstein / Frank Lyko / Timothy Yen / Kerry Bloom / James Carrington / Thomas Jenuwein
First evaluation 17 Sep 2002 | Latest evaluation 18 Oct 2002

	Exceptional
F1000 Factor 10.9

New Finding

Tech Advance

A photoactivatable GFP for selective photolabeling of proteins and cells.
Patterson GH, Lippincott-Schwartz J
Science 2002 Sep 13 297(5588):1873-7 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Ross Weatherman / Kermit Carraway / Colin Taylor / Karl Oparka / Volkhard Helms / W. Martin Usrey / Rachel Wong / Richard Maraia / Andrew Belmont
First evaluation 23 Sep 2002 | Latest evaluation 15 Nov 2002

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.