Faculty of 1000 Biology | All Time Top 10

1-Dec-2008

Top 10s

Biotechnology

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Agriculture & Biotechnology

Applied Microbiology

Biocatalysis

Chemical Biology of the Cell

Drug Discovery & Design

Environmental Microbiology

Genomics

Medical Genetics

Pharmacogenomics

Protein Chemistry & Proteomics

Small Molecule Chemistry

Structural Genomics

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	Exceptional
F1000 Factor 11.3

Confirmation

Hypothesis

New Finding

Tech Advance

Design of a novel globular protein fold with atomic-level accuracy.
Kuhlman B, Dantas G, …, Stoddard BL, Baker D
Science 2003 Nov 21 302(5649):1364-8 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Kristina Downing / Gideon Schreiber / Rob Russell / Wolfgang Guba / Nick Grishin / Padmanabhan Balaram / Robert Kelley / Kevin Plaxco / Sachdev Sidhu
First evaluation 28 Nov 2003 | Latest evaluation 3 Feb 2004

	Exceptional
F1000 Factor 10.8

Hypothesis

New Finding

Tech Advance

Transvascular delivery of small interfering RNA to the central nervous system.
Kumar P, Wu H, …, Shankar P, Manjunath N
Nature 2007 Jul 5 448(7149):39-43 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Richard Vile / Mark Kay / Angela Vincent / Marina Picciotto / Harukazu Nakamura / William H. Colledge / Günter Mayer / Michael Kiebler / Gerald Zamponi
First evaluation 3 Jul 2007 | Latest evaluation 11 Sep 2007

	Exceptional
F1000 Factor 10.8

Hypothesis

New Finding

A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.
Hegde SS, Vetting MW, …, Takiff HE, Blanchard JS
Science 2005 Jun 3 308(5727):1480-3 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Laurence Pearl / Torsten Schwede / Malcolm White / Xiayang Qiu / Brigitte Gicquel / Matt Redinbo / Peter Artymiuk / Mario Amzel / Karen Allen
First evaluation 6 Jun 2005 | Latest evaluation 25 Jul 2005

	Exceptional
F1000 Factor 10.7

Hypothesis

New Finding

A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Kimchi-Sarfaty C, Oh JM, …, Ambudkar SV, Gottesman MM
Science 2007 Jan 26 315(5811):525-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | J. Steven Leeder / Michael Roth / Richard Maraia / Sue Malcolm / William Dalton / Paul Hollenberg / Tao Pan
First evaluation 30 Jan 2007 | Latest evaluation 19 Nov 2007

	Exceptional
F1000 Factor 10.6

Hypothesis

New Finding

Structural identification of a bacterial quorum-sensing signal containing boron.
Chen X, Schauder S, …, Bassler BL, Hughson FM
Nature 2002 Jan 31 415(6871):545-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Tracy Raivio / Christoph Dehio / Wolfgang Buckel / Everett Greenberg / David Matthews / Mark Nelson / Tina Henkin / Charles Brenner / David Lambright
First evaluation 4 Feb 2002 | Latest evaluation 9 Apr 2002

	Exceptional
F1000 Factor 10.5

Confirmation

Hypothesis

New Finding

Tech Advance

Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution.
Lange OF, Lakomek NA, …, Griesinger C, de Groot BL
Science 2008 Jun 13 320(5882):1471-5 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Matthias Buck / Gottfried Otting / Antonio Rosato / Torleif Härd / Moosa Mohammadi / Thomas Szyperski
First evaluation 16 Jun 2008 | Latest evaluation 14 Jul 2008

	Exceptional
F1000 Factor 10.5

Hypothesis

New Finding

Tech Advance

Controversial

Novel Drug Target

The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, …, Kinzler KW, Velculescu VE
Science 2006-09-07 314(5797):268-74 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Channing Der / Chris Sander / Karin Schmitt / Charles Streuli / Kai Zinn / Robert Copeland
First evaluation 3 Oct 2006 | Latest evaluation 13 Dec 2006

	Exceptional
F1000 Factor 10.4

Hypothesis

New Finding

Tech Advance

Structure-based activity prediction for an enzyme of unknown function.
Hermann JC, Marti-Arbona R, …, Shoichet BK, Raushel FM
Nature 2007 Aug 16 448(7155):775-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Rowena Matthews / Michael Gelb / Karen Allen / Reinhard Sterner / Andrea Mattevi / Giulio Superti-Furga / Shelley Copley
First evaluation 30 Jul 2007 | Latest evaluation 18 Dec 2007

	Exceptional
F1000 Factor 10.4

Confirmation

New Finding

Tech Advance

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
Knight ZA, Gonzalez B, …, Williams RL, Shokat KM
Cell 2006 May 19 125(4):733-47 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Giulio Superti-Furga / Peter Mayinger / Richard Firtel / Tarun Kapoor / Steve Ward
First evaluation 15 May 2006 | Latest evaluation 7 Jun 2006

	Exceptional
F1000 Factor 10.4

Hypothesis

New Finding

Substrate-assisted catalysis of peptide bond formation by the ribosome.
Weinger JS, Parnell KM, …, Green R, Strobel SA
Nat Struct Mol Biol 2004 Nov 11(11):1101-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Reinhard Luehrmann / Arieh Warshel / Samuel Gunderson / Andrea Barta / Shelley Copley / Alfred Wittinghofer
First evaluation 16 Nov 2004 | Latest evaluation 21 Jul 2005

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.