Faculty of 1000 Biology | Current Top 10

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Cancer Biology

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Cancer Therapeutics

Cell Growth & Division

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	Must Read
F1000 Factor 6.8

Confirmation

Hypothesis

New Finding

Controversial

CTLA-4 control over Foxp3+ regulatory T cell function.
Wing K, Onishi Y, …, Nomura T, Sakaguchi S
Science 2008 Oct 10 322(5899):271-5 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Richard Williams / Kenneth Tung with Alberta Paul / Jay Berzofsky / Arthur Hurwitz / Kendall Smith
First evaluation 22 Oct 2008 | Latest evaluation 20 Nov 2008

	Must Read
F1000 Factor 6.6

Hypothesis

New Finding

A unique cell division machinery in the Archaea.
Lindås AC, Karlsson EA, …, Ettema TJ, Bernander R
Proc Natl Acad Sci U S A 2008 Nov 5 [abstract on PubMed] [related articles] [full text]

Selected by | William Margolin / Linda Amos / Harold Erickson / Mohan Balasubramanian with Ramanujam Srinivasan and Mithilesh Mishra

First evaluation 13 Nov 2008 | Latest evaluation 26 Nov 2008

	Must Read
F1000 Factor 6.6

Hypothesis

New Finding

HARP is an ATP-driven annealing helicase.
Yusufzai T, Kadonaga JT
Science 2008 Oct 31 322(5902):748-50 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Botchan / Lucio Comai / Jessica Downs
First evaluation 13 Nov 2008 | Latest evaluation 17 Nov 2008

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes.
Casar B, Pinto A, Crespo P
Mol Cell 2008 Sep 5 31(5):708-21 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Angel Nebreda / Deborah Morrison with Melissa M McKay
First evaluation 27 Oct 2008 | Latest evaluation 21 Nov 2008

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis.
Archambault V, D'Avino PP, …, Lilley KS, Glover DM
Genes Dev 2008 Oct 1 22(19):2707-20 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Robert Fisher / Kyung Lee
First evaluation 4 Nov 2008 | Latest evaluation 18 Nov 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.