Faculty of 1000 Biology | Current Top 10

21-Nov-2008

Top 10s

Biochemistry

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Biocatalysis

Bioinorganic Chemistry

Biomacromolecule-Ligand Interactions

Biomimetic Chemistry

Cell Signalling & Trafficking Structures

Chemical Biology of the Cell

Directed Molecular Evolution

Experimental Biophysical Methods

Macromolecular Assemblies & Machines

Macromolecular Chemistry

Membrane Proteins & Energy Transduction

Protein Chemistry & Proteomics

Protein Folding

Small Molecule Chemistry

Structural Genomics

Structure: RNA

Structure: Replication & Repair

Structure: Transcription & Translation

Theory & Simulation

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	Exceptional
F1000 Factor 10.1

Hypothesis

New Finding

Species-specific transcription in mice carrying human chromosome 21.
Wilson MD, Barbosa-Morais NL, …, Tavaré S, Odom DT
Science 2008 Oct 17 322(5900):434-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Yoav Gilad / Kenneth Zaret / Deyou Zheng / Julin Maloof with Jose M. Jimenez-Gomez / Lin Chen with Reza Kalhor

First evaluation 13 Oct 2008 | Latest evaluation 14 Nov 2008

	Exceptional
F1000 Factor 9.8

Hypothesis

New Finding

Tech Advance

Structure of a complex of the ATPase SecA and the protein-translocation channel.
Zimmer J, Nam Y, Rapoport TA
Nature 2008 Oct 16 455(7215):936-43 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Manfred Schliwa / Ian Collinson / Art Horwich
Evaluated 31 Oct 2008

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Protein-folding location can regulate manganese-binding versus copper- or zinc-binding.
Tottey S, Waldron KJ, …, Dennison C, Robinson NJ
Nature 2008 Oct 23 455(7216):1138-42 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Angela Wilks / John Helmann
First evaluation 3 Nov 2008 | Latest evaluation 11 Nov 2008

	Must Read
F1000 Factor 6.6

New Finding

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.
Maeda Y, Ide T, …, Uchiyama Y, Kinoshita T
Nat Cell Biol 2008 Oct 10(10):1135-45 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Sergio Grinstein with Gregory Fairn / Nathan Nelson with Alexey Amunts / Volker Haucke with Tanja Maritzen
First evaluation 22 Oct 2008 | Latest evaluation 7 Nov 2008

	Must Read
F1000 Factor 6.5

Hypothesis

New Finding

A unique cell division machinery in the Archaea.
Lindås AC, Karlsson EA, …, Ettema TJ, Bernander R
Proc Natl Acad Sci U S A 2008 Nov 5 [abstract on PubMed] [related articles] [full text]

Selected by | William Margolin / Linda Amos

/ Harold Erickson

First evaluation 13 Nov 2008 | Latest evaluation 18 Nov 2008

	Must Read
F1000 Factor 6.4

Confirmation

Hypothesis

New Finding

Caulobacter requires a dedicated mechanism to initiate chromosome segregation.
Toro E, Hong SH, McAdams HH, Shapiro L
Proc Natl Acad Sci U S A 2008 Oct 7 105(40):15435-40 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Linda Amos / Grant Jensen
First evaluation 14 Oct 2008 | Latest evaluation 23 Oct 2008

	Must Read
F1000 Factor 4.8

New Finding

Tech Advance

Extreme substrate promiscuity of the Neisseria oligosaccharyltransferase involved in protein O-glycosylation.
Faridmoayer A, Fentabil MA, …, Wang PG, Feldman MF
J Biol Chem 2008 Oct 17 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Miguel Valvano / Barbara Imperiali

First evaluation 30 Oct 2008 | Latest evaluation 19 Nov 2008

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

Tech Advance

Controversial

Remeasuring the double helix.
Mathew-Fenn RS, Das R, Harbury PA
Science 2008 Oct 17 322(5900):446-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | P. Shing Ho / Jim Maher
First evaluation 28 Oct 2008 | Latest evaluation 5 Nov 2008

	Must Read
F1000 Factor 4.8

New Finding

Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator.
Feng Y, Chen M, Manley JL
Nat Struct Mol Biol 2008 Oct 15(10):1040-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Reinhard Luehrmann / Pascale Legault
First evaluation 14 Oct 2008 | Latest evaluation 27 Oct 2008

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

Controversial

Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule lattice.
des Georges A, Katsuki M, …, Cross RA, Amos LA
Nat Struct Mol Biol 2008 Oct 15(10):1102-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Edward Egelman / Anna Akhmanova
First evaluation 17 Oct 2008 | Latest evaluation 21 Oct 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.