Faculty of 1000 Biology | Current Top 10

Top 10s

Immunology

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Allergy & Hypersensitivity

Antigen Processing & Recognition

Autoimmunity

Genetics of the Immune System

Immune Response

Immunity to Infections

Immunomodulation

Innate Immunity

Leukocyte Activation

Leukocyte Development

Leukocyte Signalling & Gene Expression

Related Sections

Cellular Microbiology & Pathogenesis

Immunopharmacology & Hematologic Pharmacology

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	Exceptional
F1000 Factor 8.3

New Finding

Novel Drug Target

ATP drives lamina propria T(H)17 cell differentiation.
Atarashi K, Nishimura J, …, Honda K, Takeda K
Nature 2008 Oct 9 455(7214):808-12 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Torben Lund / Klaus Ley / Steve Ward / Ivana Novak
First evaluation 17 Oct 2008 | Latest evaluation 29 Oct 2008

	Exceptional
F1000 Factor 8.0

New Finding

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.
Ivanov II, Frutos Rde L, …, Finlay BB, Littman DR
Cell Host Microbe 2008 Oct 16 4(4):337-49 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Klaus Ley / David Underhill
First evaluation 24 Oct 2008 | Latest evaluation 30 Oct 2008

	Must Read
F1000 Factor 6.8

Confirmation

Hypothesis

New Finding

Controversial

CTLA-4 control over Foxp3+ regulatory T cell function.
Wing K, Onishi Y, …, Nomura T, Sakaguchi S
Science 2008 Oct 10 322(5899):271-5 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Richard Williams / Kenneth Tung with Alberta Paul / Jay Berzofsky / Arthur Hurwitz / Kendall Smith
First evaluation 22 Oct 2008 | Latest evaluation 20 Nov 2008

	Must Read
F1000 Factor 6.5

Hypothesis

New Finding

Controversial

Memory CD8 T-cell compartment grows in size with immunological experience.
Vezys V, Yates A, …, Antia R, Masopust D
Nature 2008 Nov 12 [abstract on PubMed] [related articles] [full text]

Selected by | Barry Rouse / Michael McChesney / David Woodland

First evaluation 18 Nov 2008 | Latest evaluation 26 Nov 2008

	Must Read
F1000 Factor 6.5

New Finding

Novel Drug Target

Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.
Cisse B, Caton ML, …, Zhuang Y, Reizis B
Cell 2008 Oct 3 135(1):37-48 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Brigitte Huber / Marco Colonna / David Allman with Benjamin Harman
First evaluation 22 Oct 2008 | Latest evaluation 31 Oct 2008

	Must Read
F1000 Factor 6.4

Hypothesis

New Finding

Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections.
Mandl JN, Barry AP, …, Staprans SI, Feinberg MB
Nat Med 2008 Oct 14(10):1077-87 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Grant McFadden / Xiaojing Ma
First evaluation 16 Oct 2008 | Latest evaluation 29 Oct 2008

	Must Read
F1000 Factor 4.8

New Finding

Novel Drug Target

Plasmacytoid dendritic cells mediate oral tolerance.
Goubier A, Dubois B, …, Trinchieri G, Kaiserlian D
Immunity 2008 Sep 29(3):464-75 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Luciano Adorini / Maria Rescigno
First evaluation 23 Oct 2008 | Latest evaluation 24 Oct 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.