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  Sections Covered
Cell Adhesion
Cell Growth & Division
Cell Signalling
Cellular Death & Stress Responses
Control of Gene Expression
Cytoskeleton
Membranes & Sorting
Nuclear Structure & Function
Related Sections
Chemical Biology of the Cell
Developmental Molecular Mechanisms
Leukocyte Signalling & Gene Expression
Microbial Growth & Development
Microbial Physiology & Metabolism
Morphogenesis & Cell Biology
Neuronal & Glial Cell Biology
Neuronal Signalling Mechanisms
Plant Cell Biology
Plant Genetics & Gene Expression


 TOP 10 | Cell Biology | calculated on 21 November 2008
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1
Exceptional
F1000 Factor 9.8

Hypothesis
New Finding
Novel Drug Target
 Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis.
Pearce MJ, Mintseris J, …, Gygi SP, Darwin KH
Science 2008 Oct 2 [abstract on PubMed] [related articles] [full text]
Selected by | Virginia Miller / Tom Rapoport with Ann Marie Stanley / Zhen-Qiang Pan with Antonio Sarikas
First evaluation 16 Oct 2008 | Latest evaluation 6 Nov 2008
 
2
Exceptional
F1000 Factor 9.8

Hypothesis
New Finding
Tech Advance
 Structure of a complex of the ATPase SecA and the protein-translocation channel.
Zimmer J, Nam Y, Rapoport TA
Nature 2008 Oct 16 455(7215):936-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Manfred Schliwa / Ian Collinson / Art Horwich
Evaluated 31 Oct 2008
 
3
Exceptional
F1000 Factor 8.2

Hypothesis
New Finding
 Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization.
Wirtz-Peitz F, Nishimura T, Knoblich JA
Cell 2008 Oct 3 135(1):161-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Cheng-Yu Lee / Yukiko Yamashita / Valeri Vasioukhin
First evaluation 27 Oct 2008 | Latest evaluation 7 Nov 2008
 
4
Must Read
F1000 Factor 6.6

Hypothesis
New Finding
 HARP is an ATP-driven annealing helicase.
Yusufzai T, Kadonaga JT
Science 2008 Oct 31 322(5902):748-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Botchan / Lucio Comai / Jessica Downs
First evaluation 13 Nov 2008 | Latest evaluation 17 Nov 2008
 
5
Must Read
F1000 Factor 6.6

Confirmation
New Finding
 Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb.
Pryor PR, Jackson L, …, Owen DJ, Luzio JP
Cell 2008 Sep 5 134(5):817-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elizabeth Smythe / Frederick Hughson / Edwin Chapman with Colin P. Johnson / David K. Banfield
First evaluation 26 Sep 2008 | Latest evaluation 4 Nov 2008
 
6
Must Read
F1000 Factor 6.6

Hypothesis
New Finding
Novel Drug Target
 Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity.
Zhang X, Zhang G, …, Bai H, Cai D
Cell 2008 Oct 3 135(1):61-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony Means / Luis de Lecea / Y. Peng Loh
First evaluation 7 Oct 2008 | Latest evaluation 21 Oct 2008
 
7
Must Read
F1000 Factor 6.5

Hypothesis
New Finding
Novel Drug Target
 Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.
Kwon M, Godinho SA, …, Thery M, Pellman D
Genes Dev 2008 Aug 15 22(16):2189-203 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | P. Todd Stukenberg / Orly Reiner / Iain Hagan
First evaluation 20 Aug 2008 | Latest evaluation 20 Nov 2008
 
8
Must Read
F1000 Factor 6.4

New Finding
Tech Advance
 Identification of genes that regulate epithelial cell migration using an siRNA screening approach.
Simpson KJ, Selfors LM, …, Khvorova A, Brugge JS
Nat Cell Biol 2008 Aug 10 [abstract on PubMed] [related articles] [full text]
Selected by | Ron Prywes with Susanne Muehlich / C. Michael DiPersio
First evaluation 15 Sep 2008 | Latest evaluation 18 Nov 2008
 
9
Must Read
F1000 Factor 6.4

Hypothesis
New Finding
Novel Drug Target
 Modelling Myc inhibition as a cancer therapy.
Soucek L, Whitfield J, …, Nasi S, Evan GI
Nature 2008 Oct 2 455(7213):679-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Cole with Seth J. Brown / Christoph Borner
First evaluation 25 Sep 2008 | Latest evaluation 18 Nov 2008
 
10
Must Read
F1000 Factor 6.4

Hypothesis
New Finding
Tech Advance
 Detection of GTP-Tubulin Conformation in Vivo Reveals a Role for GTP Remnants in Microtubule Rescues.
Dimitrov A, Quesnoit M, …, Poüs C, Perez F
Science 2008 Oct 16 [abstract on PubMed] [related articles] [full text]
Selected by | Linda Wordeman with Jason Stumpff / Berl R. Oakley with Tetsuya Horio
First evaluation 24 Oct 2008 | Latest evaluation 6 Nov 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.

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