Faculty of 1000 Biology | Current Top 10

1-Dec-2008

Top 10s

Molecular Medicine

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Antimicrobial Agents

Autoimmunity

Cancer Therapeutics

Cardiovascular Pharmacology

Cardiovascular Physiology/Circulation

Cell Growth & Division

Drug Discovery & Design

Endocrine & Metabolic Pharmacology

Endocrinology

Gastrointestinal Pharmacology

Gastrointestinal Physiology

Genito-Urinary & Reproductive Pharmacology

Immunomodulation

Immunopharmacology & Hematologic Pharmacology

Integrative Physiology

Medical Genetics

Medical Microbiology

Molecular Pharmacology

Muscle & Connective Tissue

Musculoskeletal & Dermatologic Pharmacology

Neural Homeostasis

Neurobiology of Disease & Regeneration

Neuropharmacology & Psychopharmacology

Pharmacogenomics

Pharmacokinetics & Drug Delivery

Physiogenomics

Renal, Fluid & Electrolyte Physiology

Reproductive Physiology

Respiratory physiology

Stem Cells & Regeneration

Toxicology

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	Exceptional
F1000 Factor 8.3

New Finding

Novel Drug Target

ATP drives lamina propria T(H)17 cell differentiation.
Atarashi K, Nishimura J, …, Honda K, Takeda K
Nature 2008 Oct 9 455(7214):808-12 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Torben Lund / Klaus Ley / Steve Ward / Ivana Novak
First evaluation 17 Oct 2008 | Latest evaluation 29 Oct 2008

	Exceptional
F1000 Factor 8.2

Hypothesis

New Finding

Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization.
Wirtz-Peitz F, Nishimura T, Knoblich JA
Cell 2008 Oct 3 135(1):161-73 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Cheng-Yu Lee / Yukiko Yamashita / Valeri Vasioukhin
First evaluation 27 Oct 2008 | Latest evaluation 7 Nov 2008

	Must Read
F1000 Factor 6.8

Confirmation

Hypothesis

New Finding

Controversial

CTLA-4 control over Foxp3+ regulatory T cell function.
Wing K, Onishi Y, …, Nomura T, Sakaguchi S
Science 2008 Oct 10 322(5899):271-5 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Richard Williams / Kenneth Tung with Alberta Paul / Jay Berzofsky / Arthur Hurwitz / Kendall Smith
First evaluation 22 Oct 2008 | Latest evaluation 20 Nov 2008

	Must Read
F1000 Factor 6.6

Hypothesis

New Finding

A unique cell division machinery in the Archaea.
Lindås AC, Karlsson EA, …, Ettema TJ, Bernander R
Proc Natl Acad Sci U S A 2008 Nov 5 [abstract on PubMed] [related articles] [full text]

Selected by | William Margolin / Linda Amos / Harold Erickson / Mohan Balasubramanian with Ramanujam Srinivasan and Mithilesh Mishra

First evaluation 13 Nov 2008 | Latest evaluation 26 Nov 2008

	Must Read
F1000 Factor 6.6

Hypothesis

New Finding

HARP is an ATP-driven annealing helicase.
Yusufzai T, Kadonaga JT
Science 2008 Oct 31 322(5902):748-50 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Botchan / Lucio Comai / Jessica Downs
First evaluation 13 Nov 2008 | Latest evaluation 17 Nov 2008

	Must Read
F1000 Factor 6.5

New Finding

Novel Drug Target

Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.
Cisse B, Caton ML, …, Zhuang Y, Reizis B
Cell 2008 Oct 3 135(1):37-48 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Brigitte Huber / Marco Colonna / David Allman with Benjamin Harman
First evaluation 22 Oct 2008 | Latest evaluation 31 Oct 2008

	Must Read
F1000 Factor 6.4

Confirmation

Hypothesis

New Finding

Controversial

Novel Drug Target

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.
Cao H, Gerhold K, …, Watkins SM, Hotamisligil GS
Cell 2008 Sep 19 134(6):933-44 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Henry Ginsberg / Amira Klip with Jonathan D Schertzer

First evaluation 28 Oct 2008 | Latest evaluation 26 Nov 2008

	Must Read
F1000 Factor 6.4

New Finding

Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK.
Kim N, Stiegler AL, …, Dustin ML, Burden SJ
Cell 2008 Oct 8 [abstract on PubMed] [related articles] [full text]

Selected by | Markus Ruegg / David Ginty
First evaluation 24 Oct 2008 | Latest evaluation 31 Oct 2008

	Must Read
F1000 Factor 4.8

New Finding

Refutation

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm.
Weavers H, Prieto-Sánchez S, …, Skaer H, Denholm B
Nature 2008 Oct 29 [abstract on PubMed] [related articles] [full text]

Selected by | David Bates / Matthew Breyer

First evaluation 7 Nov 2008 | Latest evaluation 28 Nov 2008

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes.
Casar B, Pinto A, Crespo P
Mol Cell 2008 Sep 5 31(5):708-21 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Angel Nebreda / Deborah Morrison with Melissa M McKay
First evaluation 27 Oct 2008 | Latest evaluation 21 Nov 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.