Faculty of 1000 Biology | Current Top 10

Top 10s

Molecular Biology

Current Top 10

All Time Top 10

Most-viewed Top 10

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Control of Gene Expression

Nuclear Structure & Function

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	Exceptional
F1000 Factor 9.8

Hypothesis

New Finding

Novel Drug Target

Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis.
Pearce MJ, Mintseris J, …, Gygi SP, Darwin KH
Science 2008 Oct 2 [abstract on PubMed] [related articles] [full text]

Selected by | Virginia Miller / Tom Rapoport with Ann Marie Stanley / Zhen-Qiang Pan with Antonio Sarikas
First evaluation 16 Oct 2008 | Latest evaluation 6 Nov 2008

	Must Read
F1000 Factor 6.6

Hypothesis

New Finding

HARP is an ATP-driven annealing helicase.
Yusufzai T, Kadonaga JT
Science 2008 Oct 31 322(5902):748-50 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Botchan / Lucio Comai

/ Jessica Downs

First evaluation 13 Nov 2008 | Latest evaluation 17 Nov 2008

	Must Read
F1000 Factor 6.4

Hypothesis

New Finding

Novel Drug Target

Modelling Myc inhibition as a cancer therapy.
Soucek L, Whitfield J, …, Nasi S, Evan GI
Nature 2008 Oct 2 455(7213):679-83 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Cole with Seth J. Brown / Christoph Borner

First evaluation 25 Sep 2008 | Latest evaluation 18 Nov 2008

	Must Read
F1000 Factor 4.8

New Finding

Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator.
Feng Y, Chen M, Manley JL
Nat Struct Mol Biol 2008 Oct 15(10):1040-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Reinhard Luehrmann / Pascale Legault
First evaluation 14 Oct 2008 | Latest evaluation 27 Oct 2008

	Recommended
F1000 Factor 3.2

New Finding

Tech Advance

Novel Drug Target

Engineering microRNA responsiveness to decrease virus pathogenicity.
Kelly EJ, Hadac EM, Greiner S, Russell SJ
Nat Med 2008 Nov 14(11):1278-83 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | James Crowe / Lynne Maquat with Olaf Isken

First evaluation 12 Nov 2008 | Latest evaluation 19 Nov 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.