Faculty of 1000 Biology | Current Top 10

Top 10s

Genomics & Genetics

Current Top 10

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Animal Genetics

Bioinformatics

Evolutionary/Comparative Genetics

Genomics

Medical Genetics

Related Sections

Cell Growth & Division

Control of Gene Expression

Genetics of the Immune System

Microbial Evolution & Genomics

Nuclear Structure & Function

Pharmacogenomics

Physiogenomics

Plant Genetics & Gene Expression

Plant Genomes & Evolution

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	Exceptional
F1000 Factor 10.4

Hypothesis

New Finding

Species-specific transcription in mice carrying human chromosome 21.
Wilson MD, Barbosa-Morais NL, …, Tavaré S, Odom DT
Science 2008 Oct 17 322(5900):434-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Yoav Gilad / Kenneth Zaret / Deyou Zheng / Julin Maloof with Jose M. Jimenez-Gomez / Lin Chen with Reza Kalhor / Tom Misteli with Evi Soutoglou

First evaluation 13 Oct 2008 | Latest evaluation 24 Nov 2008

	Exceptional
F1000 Factor 9.8

Hypothesis

New Finding

Novel Drug Target

Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis.
Pearce MJ, Mintseris J, …, Gygi SP, Darwin KH
Science 2008 Oct 2 [abstract on PubMed] [related articles] [full text]

Selected by | Virginia Miller / Tom Rapoport with Ann Marie Stanley / Zhen-Qiang Pan with Antonio Sarikas
First evaluation 16 Oct 2008 | Latest evaluation 6 Nov 2008

	Must Read
F1000 Factor 6.6

Hypothesis

New Finding

HARP is an ATP-driven annealing helicase.
Yusufzai T, Kadonaga JT
Science 2008 Oct 31 322(5902):748-50 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Botchan / Lucio Comai / Jessica Downs
First evaluation 13 Nov 2008 | Latest evaluation 17 Nov 2008

	Must Read
F1000 Factor 6.5

New Finding

Tech Advance

Global protein stability profiling in mammalian cells.
Yen HC, Xu Q, …, Zhao Z, Elledge SJ
Science 2008 Nov 7 322(5903):918-23 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Berl R. Oakley / Hunter Fraser / Michael Lenhard
First evaluation 12 Nov 2008 | Latest evaluation 20 Nov 2008

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

A model for transmission of the H3K27me3 epigenetic mark.
Hansen KH, Bracken AP, …, Lerdrup M, Helin K
Nat Cell Biol 2008 Nov 10:1291-300 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Leonie Ringrose / Andrew Feinberg

First evaluation 6 Nov 2008 | Latest evaluation 25 Nov 2008

	Recommended
F1000 Factor 3.2

Hypothesis

New Finding

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation.
Tay Y, Zhang J, …, Lim B, Rigoutsos I
Nature 2008 Oct 23 455(7216):1124-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Yi Eve Sun with Weihong Ge

/ Peter Sarnow with Cara Pager

First evaluation 25 Nov 2008 | Latest evaluation 27 Nov 2008

	Recommended
F1000 Factor 3.2

New Finding

Tech Advance

Novel Drug Target

Engineering microRNA responsiveness to decrease virus pathogenicity.
Kelly EJ, Hadac EM, Greiner S, Russell SJ
Nat Med 2008 Nov 14(11):1278-83 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | James Crowe / Lynne Maquat with Olaf Isken
First evaluation 12 Nov 2008 | Latest evaluation 19 Nov 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.