Faculty of 1000 Biology | Current Top 10

Top 10s

Biotechnology

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Agriculture & Biotechnology

Applied Microbiology

Biocatalysis

Chemical Biology of the Cell

Drug Discovery & Design

Environmental Microbiology

Genomics

Medical Genetics

Pharmacogenomics

Protein Chemistry & Proteomics

Small Molecule Chemistry

Structural Genomics

email [Help]

	Exceptional
F1000 Factor 10.4

Hypothesis

New Finding

Species-specific transcription in mice carrying human chromosome 21.
Wilson MD, Barbosa-Morais NL, …, Tavaré S, Odom DT
Science 2008 Oct 17 322(5900):434-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Yoav Gilad / Kenneth Zaret / Deyou Zheng / Julin Maloof with Jose M. Jimenez-Gomez / Lin Chen with Reza Kalhor / Tom Misteli with Evi Soutoglou

First evaluation 13 Oct 2008 | Latest evaluation 24 Nov 2008

	Must Read
F1000 Factor 6.5

New Finding

Tech Advance

Global protein stability profiling in mammalian cells.
Yen HC, Xu Q, …, Zhao Z, Elledge SJ
Science 2008 Nov 7 322(5903):918-23 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Berl R. Oakley / Hunter Fraser / Michael Lenhard
First evaluation 12 Nov 2008 | Latest evaluation 20 Nov 2008

	Must Read
F1000 Factor 6.4

New Finding

Tech Advance

Novel Drug Target

Chemical control of protein stability and function in living mice.
Banaszynski LA, Sellmyer MA, …, Wandless TJ, Thorne SH
Nat Med 2008 Oct 14(10):1123-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Ken Irvine with Yongqiang Feng / Thomas W. von Geldern
First evaluation 20 Nov 2008 | Latest evaluation 21 Nov 2008

	Must Read
F1000 Factor 4.8

New Finding

Tech Advance

Novel Drug Target

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Apsel B, Blair JA, …, Shokat KM, Knight ZA
Nat Chem Biol 2008 Nov 4(11):691-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Robert Abraham / David Triggle

First evaluation 7 Nov 2008 | Latest evaluation 27 Nov 2008

	Must Read
F1000 Factor 4.8

New Finding

Tech Advance

Extreme substrate promiscuity of the Neisseria oligosaccharyltransferase involved in protein O-glycosylation.
Faridmoayer A, Fentabil MA, …, Wang PG, Feldman MF
J Biol Chem 2008 Oct 17 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Miguel Valvano / Barbara Imperiali
First evaluation 30 Oct 2008 | Latest evaluation 19 Nov 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.