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1: J Am Chem Soc. 2008 Sep 24;130(38):12636-8. Epub 2008 Sep 3.
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Selecting aptamers for a glycoprotein through the incorporation of the boronic acid moiety.

Li M, Lin N, Huang Z, Du L, Altier C, Fang H, Wang B.

Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30302-4098, USA.

The first general method for the selection of boronic acid-based aptamers (boronolectins) that allows for glycan substructure focusing is described. Using fibrinogen as a model glycoprotein, we have selected boronic acid-modified DNA aptamers that have high affinities (low nM Kd) and the ability to recognize changes in the glycosylation site. The method developed should also be applicable to the development of aptamers for other glycoproducts, such as glycolipids and glycopeptides.

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PMID: 18763762 [PubMed - in process]