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1: Nat Chem Biol. 2008 Mar;4(3):194-6. Epub 2008 Feb 10.
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Adenosyltransferase tailors and delivers coenzyme B12.

Padovani D, Labunska T, Palfey BA, Ballou DP, Banerjee R.

Biological Chemistry Department, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-0606, USA.

The reactivity and relative rarity of most cofactors pose challenges for their delivery to target enzymes. Using kinetic analyses, we demonstrate that adenosyltransferase, which catalyzes the final step in the assimilation of coenzyme B12, directly transfers the cofactor to methylmalonyl coenzyme A mutase. The strategy of using the final enzyme in an assimilation pathway for tailoring a cofactor and delivering it to a dependent enzyme may be general for cofactor trafficking.

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PMID: 18264093 [PubMed - indexed for MEDLINE]