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1: Science. 2004 May 14;304(5673):983-7. Epub 2004 Apr 15.
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Oscillating global regulators control the genetic circuit driving a bacterial cell cycle.

Holtzendorff J, Hung D, Brende P, Reisenauer A, Viollier PH, McAdams HH, Shapiro L.

Department of Developmental Biology, School of Medicine, Beckman Center, Stanford University, Stanford, CA 94305, USA.

A newly identified cell-cycle master regulator protein, GcrA, together with the CtrA master regulator, are key components of a genetic circuit that drives cell-cycle progression and asymmetric polar morphogenesis in Caulobacter crescentus. The circuit drives out-of-phase temporal and spatial oscillation of GcrA and CtrA concentrations, producing time- and space-dependent transcriptional regulation of modular functions that implement cell-cycle processes. The CtrA/GcrA regulatory circuit controls expression of polar differentiation factors and the timing of DNA replication. CtrA functions as a silencer of the replication origin and GcrA as an activator of components of the replisome and the segregation machinery.

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PMID: 15087506 [PubMed - indexed for MEDLINE]