Your browser version may not work well with NCBI's Web applications. More information here...
1: Nat Immunol. 2003 Jul;4(7):680-6. Epub 2003 Jun 15.
Related Articles, Links
Click here to read Click here to read
Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells.

Seddon B, Tomlinson P, Zamoyska R.

Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

Immunological memory depends on the long-term maintenance of memory T cells. Although the factors that maintain CD8 T cell memory are well understood, those responsible for CD4 memory are not well defined. We have shown here that interleukin 7 (IL-7) was an important survival factor for CD4 memory T cells that together with T cell receptor (TCR) signals regulated homeostasis of the CD4 memory population in lymphopenic conditions and in the intact immune system. Thus, IL-7 contributes to the maintenance of all naive and memory T cell subsets, and therefore controls the overall size of the T cell pool.

Publication Types:
PMID: 12808452 [PubMed - indexed for MEDLINE]