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Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Novel Drug Target
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.
Park KK, Liu K, …, Sahin M, He Z
Science 2008 Nov 7 322(5903):963-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Vance Lemmon with Jessica K Lerch-Haner
Evaluated 28 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints.
Li X, Ito M, …, Leder P, Ferguson-Smith AC
Dev Cell 2008 Oct 15(4):547-57 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 25 Nov 2008

Recommended
F1000 Factor 3.2

Hypothesis
New Finding
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation.
Tay Y, Zhang J, …, Lim B, Rigoutsos I
Nature 2008 Oct 23 455(7216):1124-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yi Eve Sun with Weihong Ge / Peter Sarnow with Cara Pager
First evaluation 25 Nov 2008 | Latest evaluation 27 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity.
Ullah Z, Kohn MJ, …, Vassilev LT, Depamphilis ML
Genes Dev 2008 Nov 1 22(21):3024-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marcel Mechali
Evaluated 21 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation.
Luis TC, Weerkamp F, …, van Dongen JJ, Staal FJ
Blood 2008 Oct 2 [abstract on PubMed] [related articles] [full text]
Selected by | Hans-Willem Snoeck
Evaluated 21 Nov 2008

Must Read
F1000 Factor 4.8

New Finding
Novel Drug Target
Rac activation and inactivation control plasticity of tumor cell movement.
Sanz-Moreno V, Gadea G, …, Sahai E, Marshall CJ
Cell 2008 Oct 31 135(3):510-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Richard Klemke / Martin A. Schwartz
First evaluation 13 Nov 2008 | Latest evaluation 24 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin.
Kanatsu-Shinohara M, Takehashi M, …, Fässler R, Shinohara T
Cell Stem Cell 2008 Nov 6 3(5):533-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Erika Matunis
Evaluated 13 Nov 2008

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Tech Advance
Global reorganization of replication domains during embryonic stem cell differentiation.
Hiratani I, Ryba T, …, Schübeler D, Gilbert DM
PLoS Biol 2008 Oct 7 6(10):e245 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joel Huberman
Evaluated 11 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation.
Duncan EM, Muratore-Schroeder TL, …, Hunt DF, Allis CD
Cell 2008 Oct 17 135(2):284-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Cole with Seth J. Brown
Evaluated 7 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.
Mohn F, Weber M, …, Bibel M, Schübeler D
Mol Cell 2008 Jun 20 30(6):755-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Magdalena Götz
Evaluated 29 Oct 2008


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