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Browse > Pharmacology & Drug Discovery > Toxicology
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Recommended
F1000 Factor 3.0

New Finding
 Testosterone for low libido in postmenopausal women not taking estrogen.
Davis SR, Moreau M, …, Studd J, APHRODITE Study Team
N Engl J Med 2008 Nov 6 359(19):2005-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Amory
Evaluated 17 Nov 2008

Exceptional
F1000 Factor 9.0

Hypothesis
Controversial
 Philip Morris's health information web site appears responsible but undermines public health.
Smith EA, Malone RE
Public Health Nurs 2008 Nov-Dec 25(6):554-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Neil Grunberg
Evaluated 10 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Structures of human cytochrome P450 2E1: insights into the binding of inhibitors and both small molecular weight and fatty acid substrates.
Porubsky PR, Meneely KM, Scott EE
J Biol Chem 2008 Sep 24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elizabeth Gillam
Evaluated 6 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
Controversial
Novel Drug Target
 On the action potential as a propagating density pulse and the role of anesthetics.
Heimburg T, Jackson AD
BRL 2007 2:57-78 [full text]
Selected by | Etienne Joly with Thomas Portet
Evaluated 5 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Doxorubicin induces early lipid peroxidation associated with changes in glucose transport in cultured cardiomyocytes.
Hrelia S, Fiorentini D, …, Biagi PL, Hakim G
Biochim Biophys Acta 2002 Dec 23 1567(1-2):150-6 [abstract on PubMed] [related articles] [order article]
Selected by | Michael Reid with Melissa Chambers
Evaluated 29 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.
Ahn BH, Kim HS, …, Deng CX, Finkel T
Proc Natl Acad Sci U S A 2008 Sep 23 105(38):14447-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lawrence Lash
Evaluated 27 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Disrupted secretory activation of the mammary gland after antenatal glucocorticoid treatment in sheep.
Henderson JJ, Hartmann PE, …, Doherty DA, Newnham JP
Reproduction 2008 Nov 136(5):649-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ray Rodgers
Evaluated 27 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
Novel Drug Target
 Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.
Ericson E, Gebbia M, …, Giaever G, Nislow C
PLoS Genet 2008 4(8):e1000151 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ramon Serrano
Evaluated 20 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
Tech Advance
 Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat.
Andersen ME, Clewell HJ, …, Willson GA, Thomas RS
Toxicol Sci 2008 Oct 105(2):368-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruce Car with Stefan Ruepp
Evaluated 20 Oct 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease.
Bradford BU, O'Connell TM, …, Kono H, Rusyn I
Toxicol Appl Pharmacol 2008 Jul 12 232 [abstract on PubMed] [related articles] [full text]
Selected by | Michael Cunningham
Evaluated 16 Oct 2008


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