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Browse > Pharmacology & Drug Discovery > Genito-Urinary & Reproductive Pharmacology
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Must Read
F1000 Factor 6.0

Confirmation
 Identification of alpha(1L)-adrenoceptor in mice and its abolition by alpha(1A)-adrenoceptor gene knockout.
Muramatsu I, Morishima S, …, Myagmar BE, Simpson PC
Br J Pharmacol 2008 Sep 22 [abstract on PubMed] [related articles] [full text]
Selected by | Rodolfo Testa with Patrizia Angelico
Evaluated 1 Dec 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer.
Locke JA, Guns ES, …, Gleave ME, Nelson CC
Cancer Res 2008 Aug 1 68(15):6407-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alvin Matsumoto
Evaluated 21 Nov 2008

Recommended
F1000 Factor 3.0

Controversial
 The involvement of urothelial alpha1A adrenergic receptor in controlling the micturition reflex.
Yanase H, Wang X, …, Nimura T, Kawatani M
Biomed Res 2008 Oct 29(5):239-44 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rodolfo Testa with Patrizia Angelico
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Testosterone for low libido in postmenopausal women not taking estrogen.
Davis SR, Moreau M, …, Studd J, APHRODITE Study Team
N Engl J Med 2008 Nov 6 359(19):2005-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Amory
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
Novel Drug Target
 Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer.
Gupta D, Venkatesh M, …, Longley C, Mani S
Clin Cancer Res 2008 Sep 1 14(17):5332-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan Bates
Evaluated 4 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Controversial
Novel Drug Target
 The role of melanin-concentrating hormone-1 (MCH1) receptors in the voiding reflex in rats.
Hegde LG, Ping XL, Jochnowitz N, Craig DA
J Pharmacol Exp Ther 2008 Oct 10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rodolfo Testa with Patrizia Angelico
Evaluated 28 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Disrupted secretory activation of the mammary gland after antenatal glucocorticoid treatment in sheep.
Henderson JJ, Hartmann PE, …, Doherty DA, Newnham JP
Reproduction 2008 Nov 136(5):649-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ray Rodgers
Evaluated 27 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
Novel Drug Target
 The Role of p75NTR in Female Rat Urinary Bladder with Cyclophosphamide (CYP)-Induced Cystitis.
Klinger MB, Vizzard MA
Am J Physiol Renal Physiol 2008 Oct 8 [abstract on PubMed] [related articles] [full text]
Selected by | Rodolfo Testa
Evaluated 24 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Role of alpha(1)-adrenergic receptors in detrusor overactivity induced by cold stress in conscious rats.
Chen Z, Ishizuka O, …, Nishizawa O, Andersson KE
Neurourol Urodyn 2008 Oct 6 [abstract on PubMed] [related articles] [full text]
Selected by | Rodolfo Testa with Patrizia Angelico
Evaluated 23 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
Novel Drug Target
 Synthetic glycopeptide vaccines combining beta-mannan and peptide epitopes induce protection against candidiasis.
Xin H, Dziadek S, Bundle DR, Cutler JE
Proc Natl Acad Sci U S A 2008 Sep 9 105(36):13526-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arturo Casadevall
Evaluated 16 Oct 2008


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