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Browse > Pharmacology & Drug Discovery > Gastrointestinal Pharmacology
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Recommended
F1000 Factor 3.0

Confirmation
 Purinergic receptors and synaptic transmission in enteric neurons.
Ren J, Bertrand PP
Purinergic Signal 2008 Sep 4(3):255-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey Burnstock
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.
Cenac N, Altier C, …, Zamponi G, Vergnolle N
Gastroenterology 2008 Sep 135(3):937-46, 946.e1-2 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Indu Ambudkar
Evaluated 29 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function.
Ewaschuk JB, Diaz H, …, Looijer-van Langen M, Madsen KL
Am J Physiol Gastrointest Liver Physiol 2008 Sep 11 [abstract on PubMed] [related articles] [full text]
Selected by | Helen Raybould
Evaluated 29 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
Stebbins JL, De SK, …, Karin M, Pellecchia M
Proc Natl Acad Sci U S A 2008 Oct 15 [abstract on PubMed] [related articles] [full text]
Selected by | Jefferson Tilley
Evaluated 24 Oct 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.
Shi ZC, Devasagayaraj A, …, Wilson A, Liu Q
J Med Chem 2008 Jul 10 51(13):3684-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas W. von Geldern
Evaluated 23 Oct 2008

Must Read
F1000 Factor 4.8

New Finding
Novel Drug Target
 Plasmacytoid dendritic cells mediate oral tolerance.
Goubier A, Dubois B, …, Trinchieri G, Kaiserlian D
Immunity 2008 Sep 29(3):464-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Luciano Adorini / Maria Rescigno
First evaluation 23 Oct 2008 | Latest evaluation 24 Oct 2008

Exceptional
F1000 Factor 8.3

New Finding
Novel Drug Target
 ATP drives lamina propria T(H)17 cell differentiation.
Atarashi K, Nishimura J, …, Honda K, Takeda K
Nature 2008 Oct 9 455(7214):808-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Torben Lund / Klaus Ley / Steve Ward / Ivana Novak
First evaluation 17 Oct 2008 | Latest evaluation 29 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Novel Drug Target
 The G protein-coupled receptor G2A: involvement in hepatic lipid metabolism and gallstone formation in mice.
Johnson LE, Elias MS, …, Green RM, Hedrick CC
Hepatology 2008 Oct 48(4):1138-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 16 Oct 2008

Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
 P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity.
Xu GY, Shenoy M, …, Mittal S, Pasricha PJ
Gut 2008 Sep 57(9):1230-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey Burnstock
Evaluated 3 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.
Fujishita T, Aoki K, …, Aoki M, Taketo MM
Proc Natl Acad Sci U S A 2008 Sep 9 105(36):13544-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mariann Bienz
Evaluated 22 Sep 2008


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