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Browse > Pharmacology & Drug Discovery > Endocrine & Metabolic Pharmacology
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Must Read
F1000 Factor 6.0

New Finding
 Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.
Montero J, Morales A, …, Colell A, Fernández-Checa JC
Cancer Res 2008 Jul 1 68(13):5246-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Andrews
Evaluated 19 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines.
Anagnostou SH, Shepherd PR
Biochem J 2008 Dec 1 416(2):211-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alex Toker
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
Novel Drug Target
 Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal.
Surget A, Saxe M, …, Hen R, Belzung C
Biol Psychiatry 2008 Aug 15 64(4):293-301 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Esther Sternberg with Marni Silverman
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Testosterone for low libido in postmenopausal women not taking estrogen.
Davis SR, Moreau M, …, Studd J, APHRODITE Study Team
N Engl J Med 2008 Nov 6 359(19):2005-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Amory
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
Song B, Scheuner D, …, Pennathur S, Kaufman RJ
J Clin Invest 2008 Oct 118(10):3378-89 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Raghavendra Mirmira
Evaluated 11 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Attenuation of amydgala and frontal cortical responses to low blood glucose concentration in asymptomatic hypoglycemia in type 1 diabetes: a new player in hypoglycemia unawareness?
Dunn JT, Cranston I, …, Amiel SA, Reed LJ
Diabetes 2007 Nov 56(11):2766-73 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Achim Peters
Evaluated 6 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.
Koulmanda M, Bhasin M, …, Flier JS, Strom TB
Proc Natl Acad Sci U S A 2008 Oct 21 105(42):16242-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Atkinson
Evaluated 4 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Prenatal psychosocial stress exposure is associated with insulin resistance in young adults.
Entringer S, Wüst S, …, Hellhammer DH, Wadhwa PD
Am J Obstet Gynecol 2008 Apr 28 [abstract on PubMed] [related articles] [full text]
Selected by | Achim Peters
Evaluated 3 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.
Semple G, Fioravanti B, …, Leonard J, Jones RM
J Med Chem 2008 Sep 11 51(17):5172-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roger Freidinger
Evaluated 31 Oct 2008

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Controversial
Novel Drug Target
 Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.
Cao H, Gerhold K, …, Watkins SM, Hotamisligil GS
Cell 2008 Sep 19 134(6):933-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Henry Ginsberg
Evaluated 28 Oct 2008


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