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Browse > Pharmacology & Drug Discovery > Neuropharmacology & Psychopharmacology
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Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
Novel Drug Target
 Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal.
Surget A, Saxe M, …, Hen R, Belzung C
Biol Psychiatry 2008 Aug 15 64(4):293-301 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Esther Sternberg with Marni Silverman
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Neural circuitry of stress-induced insomnia in rats.
Cano G, Mochizuki T, Saper CB
J Neurosci 2008 Oct 1 28(40):10167-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Luis de Lecea
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase.
Behrens MM, Ali SS, …, Quick KL, Dugan LL
Science 2007 Dec 7 318(5856):1645-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Emery Brown
Evaluated 17 Nov 2008


Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Du H, Guo L, …, Chen JX, Yan SD
Nat Med 2008 Oct 14(10):1097-105 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heinz Osiewacz
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 PirB is a functional receptor for myelin inhibitors of axonal regeneration.
Atwal JK, Pinkston-Gosse J, …, Shatz C, Tessier-Lavigne M
Science 2008 Nov 7 322(5903):967-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan K. McConnell
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
Controversial
Novel Drug Target
 Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression.
Ghia JE, Blennerhassett P, Collins SM
J Clin Invest 2008 Jun 118(6):2209-18 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ruud Buijs
Evaluated 14 Nov 2008

Exceptional
F1000 Factor 9.0

New Finding
Controversial
Refutation
 Increased cognitive functioning in symptomatic Huntington's disease as revealed by behavioral and event-related potential indices of auditory sensory memory and attention.
Beste C, Saft C, Güntürkün O, Falkenstein M
J Neurosci 2008 Nov 5 28(45):11695-702 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jerry Buccafusco
Evaluated 12 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Yang ZQ, Barrow JC, …, Koblan KS, Renger JJ
J Med Chem 2008 Oct 23 51(20):6471-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 12 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
 Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and losses.
Petrovic P, Pleger B, …, Critchley H, Dolan RJ
J Neurosci 2008 Oct 15 28(42):10509-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kent Berridge
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model.
Desroches J, Guindon J, Lambert C, Beaulieu P
Br J Pharmacol 2008 Aug 11 [abstract on PubMed] [related articles] [full text]
Selected by | Roger Pertwee with Maria-Grazia Cascio
Evaluated 10 Nov 2008


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