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Recommended
F1000 Factor 3.0

Hypothesis
 Stimulation of Ebola virus production from persistent infection through activation of the Ras/MAPK pathway.
Strong JE, Wong G, …, Kobinger GP, Feldmann H
Proc Natl Acad Sci U S A 2008 Nov 3 105 [abstract on PubMed] [related articles] [full text]
Selected by | Kanta Subbarao with Catherine Luke
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Substituted 2-Imino-5-arylidenethiazolidin-4-one Inhibitors of Bacterial Type III Secretion.
Kline T, Felise HB, …, Nguyen HV, Miller SI
J Med Chem 2008 Oct 24 0 [abstract on PubMed] [related articles] [full text]
Selected by | Robert Fecik
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.2

New Finding
Tech Advance
Novel Drug Target
 Engineering microRNA responsiveness to decrease virus pathogenicity.
Kelly EJ, Hadac EM, Greiner S, Russell SJ
Nat Med 2008 Nov 14(11):1278-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Crowe / Lynne Maquat with Olaf Isken
First evaluation 12 Nov 2008 | Latest evaluation 19 Nov 2008

Must Read
F1000 Factor 6.0

Tech Advance
Novel Drug Target
 The potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent.
Banin E, Lozinski A, …, Greenberg EP, Banin E
Proc Natl Acad Sci U S A 2008 Oct 28 105(43):16761-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kim Lewis with Lawrence R. Mulcahy
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Tech Advance
 Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold.
Heidema J, Rossen JW, …, Kimpen JL, van Bleek GM
J Immunol 2008 Oct 15 181(8):5551-9 [abstract on PubMed] [related articles] [order article]
Selected by | Peter Openshaw
Evaluated 10 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Pesu M, Watford WT, …, Creemers J, O'Shea JJ
Nature 2008 Sep 11 455(7210):246-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Fuller
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Neutrophil elastase mediates innate host protection against Pseudomonas aeruginosa.
Hirche TO, Benabid R, …, Hancock RE, Belaaouaj A
J Immunol 2008 Oct 1 181(7):4945-54 [abstract on PubMed] [related articles] [order article]
Selected by | Joanna Goldberg
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 HilD-mediated transcriptional cross-talk between SPI-1 and SPI-2.
Bustamante VH, Martínez LC, …, Steele-Mortimer O, Puente JL
Proc Natl Acad Sci U S A 2008 Sep 23 105(38):14591-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Charles J. Dorman
Evaluated 6 Nov 2008

Must Read
F1000 Factor 4.8

New Finding
Tech Advance
 Extreme substrate promiscuity of the Neisseria oligosaccharyltransferase involved in protein O-glycosylation.
Faridmoayer A, Fentabil MA, …, Wang PG, Feldman MF
J Biol Chem 2008 Oct 17 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Miguel Valvano / Barbara Imperiali
First evaluation 30 Oct 2008 | Latest evaluation 19 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Novel Drug Target
 Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine?
Wilson RA, Langermans JA, …, Thomas AW, Coulson PS
PLoS Negl Trop Dis 2008 2(9):e290 [abstract on PubMed] [related articles] [FREE full text]
Selected by | W. Evan Secor
Evaluated 29 Oct 2008


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