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Recommended
F1000 Factor 3.0

New Finding
 Rhesus macaque rhadinovirus-associated non-Hodgkin lymphoma: animal model for KSHV-associated malignancies.
Orzechowska BU, Powers MF, …, Axthelm MK, Wong SW
Blood 2008 Nov 15 112(10):4227-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Blossom Damania
Evaluated 28 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
Sonveaux P, Végran F, …, Feron O, Dewhirst MW
J Clin Invest 2008 Nov 20 [abstract on PubMed] [related articles] [full text]
Selected by | Robert Abraham
Evaluated 27 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.
Hurtado A, Holmes KA, …, Ali S, Carroll JS
Nature 2008 Nov 12 [abstract on PubMed] [related articles] [full text]
Selected by | Christopher Ormandy with Heather Lee
Evaluated 26 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus.
Lagos D, Vart RJ, …, Gotch F, Boshoff C
Cell Host Microbe 2008 Nov 13 4(5):470-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick S. Moore with Saumendra Sarkar
Evaluated 24 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.
Caswell PT, Chan M, …, Boettiger D, Norman JC
J Cell Biol 2008 Oct 6 183(1):143-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Casanova
Evaluated 21 Nov 2008

Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
Novel Drug Target
 DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
Ley TJ, Mardis ER, …, DiPersio JF, Wilson RK
Nature 2008 Nov 6 456(7218):66-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Charles Auffray
Evaluated 21 Nov 2008

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F1000 Factor 6.0

Hypothesis
New Finding
 Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer.
Locke JA, Guns ES, …, Gleave ME, Nelson CC
Cancer Res 2008 Aug 1 68(15):6407-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alvin Matsumoto
Evaluated 21 Nov 2008

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F1000 Factor 3.0

Hypothesis
New Finding
 Chromosomal instability in unirradiated hematopoietic cells induced by macrophages exposed in vivo to ionizing radiation.
Lorimore SA, Chrystal JA, …, Coates PJ, Wright EG
Cancer Res 2008 Oct 1 68:8122-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Len Neckers
Evaluated 20 Nov 2008

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F1000 Factor 6.4

New Finding
Tech Advance
Novel Drug Target
 Chemical control of protein stability and function in living mice.
Banaszynski LA, Sellmyer MA, …, Wandless TJ, Thorne SH
Nat Med 2008 Oct 14(10):1123-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine with Yongqiang Feng / Thomas W. von Geldern
First evaluation 20 Nov 2008 | Latest evaluation 21 Nov 2008

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F1000 Factor 6.0

New Finding
 Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.
Montero J, Morales A, …, Colell A, Fernández-Checa JC
Cancer Res 2008 Jul 1 68(13):5246-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Andrews
Evaluated 19 Nov 2008


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