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Browse > Pharmacology & Drug Discovery > Drug Discovery & Design
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Must Read
F1000 Factor 6.0

Hypothesis
 Predicting molecules--more realism, please!
Hoffmann R, Schleyer PR, Schaefer HF
Angew Chem Int Ed Engl 2008 47(38):7164-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 20 Nov 2008

Must Read
F1000 Factor 6.0

Tech Advance
Novel Drug Target
 Chemical control of protein stability and function in living mice.
Banaszynski LA, Sellmyer MA, …, Wandless TJ, Thorne SH
Nat Med 2008 Oct 14(10):1123-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine with Yongqiang Feng
Evaluated 20 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I IFN, and immune suppression.
Malleret B, Maneglier B, …, Le Grand R, Vaslin B
Blood 2008 Sep 11 [abstract on PubMed] [related articles] [full text]
Selected by | Gene Shearer with Adriano Boasso
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Molecular Engineering of Photoremovable Protecting Groups for Two-Photon Uncaging.
Gug S, Bolze F, …, Goeldner M, Nicoud JF
Angew Chem Int Ed Engl 2008 Oct 29 [abstract on PubMed] [related articles] [full text]
Selected by | Michael Pirrung
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge.
Kotoku N, Hiramatsu A, …, Aoki S, Kobayashi M
Arch Pharm (Weinheim) 2008 Sep 341(9):568-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tadeusz Molinski
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
Tech Advance
Novel Drug Target
 Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells.
Fujikawa Y, Urano Y, …, Inoue H, Nagano T
J Am Chem Soc 2008 Nov 5 130(44):14533-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hening Lin
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

Tech Advance
Novel Drug Target
 Generating Arrays with High Content and Minimal Consumption of Functional Membrane Proteins.
Majd S, Mayer M
J Am Chem Soc 2008 Nov 1 0 [abstract on PubMed] [related articles] [full text]
Selected by | Ross Weatherman
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 A small molecule enhances RNA interference and promotes microRNA processing.
Shan G, Li Y, …, He C, Jin P
Nat Biotechnol 2008 Aug 26(8):933-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gabriele Varani
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Du H, Guo L, …, Chen JX, Yan SD
Nat Med 2008 Oct 14(10):1097-105 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heinz Osiewacz
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.
Abdo M, Liu S, …, Knapp S, Zhang ZY
J Am Chem Soc 2008 Oct 8 130(40):13196-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Cole
Evaluated 14 Nov 2008


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