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Browse > Pharmacology & Drug Discovery > Pharmacokinetics & Drug Delivery
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Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Structures of human cytochrome P450 2E1: insights into the binding of inhibitors and both small molecular weight and fatty acid substrates.
Porubsky PR, Meneely KM, Scott EE
J Biol Chem 2008 Sep 24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elizabeth Gillam
Evaluated 6 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
 Genetic variation in human P450 oxidoreductase.
Miller WL, Huang N, Agrawal V, Giacomini KM
Mol Cell Endocrinol 2008 Sep 26 [abstract on PubMed] [related articles] [full text]
Selected by | Magnus Ingelman-Sundberg
Evaluated 4 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
Novel Drug Target
 Targeted Single-Wall Carbon Nanotube-Mediated Pt(IV) Prodrug Delivery Using Folate as a Homing Device
Dhar S, Liu Z, …, Dai H, Lippard SJ
Journal of the American Chemical Society 2008 130:11467-11476 [full text]
Selected by | James Cowan
Evaluated 27 Oct 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.
Shi ZC, Devasagayaraj A, …, Wilson A, Liu Q
J Med Chem 2008 Jul 10 51(13):3684-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas W. von Geldern
Evaluated 23 Oct 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
Controversial
 Mechanisms underlying saturable intestinal absorption of metformin.
Proctor WR, Bourdet DL, Thakker DR
Drug Metab Dispos 2008 Aug 36(8):1650-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Amnon Hoffman
Evaluated 20 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Controversial
 Drug interactions modulate the potential for evolution of resistance.
Michel JB, Yeh PJ, …, Moellering RC, Kishony R
Proc Natl Acad Sci U S A 2008 Sep 30 105(39):14918-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Roepe
Evaluated 20 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
 Evidence that the anticarcinogenic effect of caffeic acid phenethyl ester in the resistant hepatocyte model involves modifications of cytochrome P450.
Beltrán-Ramírez O, Alemán-Lazarini L, …, Sierra-Santoyo A, Villa-Treviño S
Toxicol Sci 2008 Jul 104(1):100-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Howard Glauert
Evaluated 7 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
Tech Advance
 Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.
Maeder ML, Thibodeau-Beganny S, …, Voytas DF, Joung JK
Mol Cell 2008 Jul 25 31(2):294-301 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Brian Kuhlman
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 A domino effect in antifolate drug action in Escherichia coli.
Kwon YK, Lu W, …, Bognar A, Rabinowitz JD
Nat Chem Biol 2008 Oct 4(10):602-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ruma Banerjee
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Intracellular protein delivery activity of peptides derived from insulin-like growth factor binding proteins 3 and 5.
Goda N, Tenno T, …, Tanaka T, Hiroaki H
Exp Cell Res 2008 Aug 1 314(13):2352-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven A. Rosenzweig
Evaluated 1 Oct 2008


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