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F1000 Factor 3.0

Hypothesis
New Finding
Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.
Yago T, Lou J, …, McEver RP, Zhu C
J Clin Invest 2008 Sep 118(9):3195-207 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Xiaoping Du
Evaluated 20 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge.
Kotoku N, Hiramatsu A, …, Aoki S, Kobayashi M
Arch Pharm (Weinheim) 2008 Sep 341(9):568-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tadeusz Molinski
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity.
Lee SS, Cha EY, …, Yeo CW, Shin JG
Hepatology 2008 Aug 48(2):635-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Controversial
The involvement of urothelial alpha1A adrenergic receptor in controlling the micturition reflex.
Yanase H, Wang X, …, Nimura T, Kawatani M
Biomed Res 2008 Oct 29(5):239-44 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rodolfo Testa with Patrizia Angelico
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Tech Advance
Novel Drug Target
Generating Arrays with High Content and Minimal Consumption of Functional Membrane Proteins.
Majd S, Mayer M
J Am Chem Soc 2008 Nov 1 0 [abstract on PubMed] [related articles] [full text]
Selected by | Ross Weatherman
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
PirB is a functional receptor for myelin inhibitors of axonal regeneration.
Atwal JK, Pinkston-Gosse J, …, Shatz C, Tessier-Lavigne M
Science 2008 Nov 7 322(5903):967-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan K. McConnell
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
Anatomical profiling of G protein-coupled receptor expression.
Regard JB, Sato IT, Coughlin SR
Cell 2008 Oct 31 135(3):561-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Soeren Sheikh
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
Refutation
Novel Drug Target
Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.
Baxter NJ, Blackburn GM, …, Wemmer DE, Waltho JP
J Am Chem Soc 2008 Mar 26 130(12):3952-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arieh Warshel with Shina Caroline Lynn Kamerlin
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.
Jackson NE, Wang HW, …, Cairns J, Hunt JE
J Biol Chem 2008 Oct 14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard L. Stevens
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Agonist-selective, Receptor-specific Interaction of Human P2Y Receptors with {beta}-Arrestin-1 and -2.
Hoffmann C, Ziegler N, …, Krasel C, Lohse MJ
J Biol Chem 2008 Nov 7 283(45):30933-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ralf Jockers with Maud Kamal
Evaluated 13 Nov 2008


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