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Recommended
F1000 Factor 3.0

New Finding
 Rhesus macaque rhadinovirus-associated non-Hodgkin lymphoma: animal model for KSHV-associated malignancies.
Orzechowska BU, Powers MF, …, Axthelm MK, Wong SW
Blood 2008 Nov 15 112(10):4227-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Blossom Damania
Evaluated 28 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.
Yang G, Wu L, …, Snyder SH, Wang R
Science 2008 Oct 24 322(5901):587-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Robertson
Evaluated 27 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Novel genes dramatically alter regulatory network topology in amphioxus.
Zhang Q, Zmasek CM, …, Litman GW, Godzik A
Genome Biol 2008 9(8):R123 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Tony De Tomaso
Evaluated 26 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 A single-cell view on the ecophysiology of anaerobic phototrophic bacteria.
Musat N, Halm H, …, Jørgensen BB, Kuypers MM
Proc Natl Acad Sci U S A 2008 Nov 18 105(46):17861-17866 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Wagner
Evaluated 26 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats.
Calle C, Maestro B, García-Arencibia M
BMC Mol Biol 2008 9:65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carolyn Ecelbarger
Evaluated 25 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus.
Lagos D, Vart RJ, …, Gotch F, Boshoff C
Cell Host Microbe 2008 Nov 13 4(5):470-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick S. Moore with Saumendra Sarkar
Evaluated 24 Nov 2008

Must Read
F1000 Factor 6.0

Tech Advance
 Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases.
Redondo P, Prieto J, …, Blanco FJ, Montoya G
Nature 2008 Nov 6 456(7218):107-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ulf Pettersson
Evaluated 21 Nov 2008

Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
Novel Drug Target
 DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
Ley TJ, Mardis ER, …, DiPersio JF, Wilson RK
Nature 2008 Nov 6 456(7218):66-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Charles Auffray
Evaluated 21 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
Controversial
 A Functional Genetic Link between Distinct Developmental Language Disorders.
Vernes SC, Newbury DF, …, Monaco AP, Fisher SE
N Engl J Med 2008 Nov 5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Isaac Kohane
Evaluated 21 Nov 2008

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F1000 Factor 6.4

New Finding
Tech Advance
 Alternative isoform regulation in human tissue transcriptomes.
Wang ET, Sandberg R, …, Schroth GP, Burge CB
Nature 2008 Nov 2 456(7221):470-476 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine with Yongqiang Feng / Donald Rio
First evaluation 20 Nov 2008 | Latest evaluation 1 Dec 2008


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