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Recommended
F1000 Factor 3.0

New Finding
 Persistent epigenetic differences associated with prenatal exposure to famine in humans.
Heijmans BT, Tobi EW, …, Slagboom PE, Lumey LH
Proc Natl Acad Sci U S A 2008 Nov 4 105(44):17046-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Testosterone for low libido in postmenopausal women not taking estrogen.
Davis SR, Moreau M, …, Studd J, APHRODITE Study Team
N Engl J Med 2008 Nov 6 359(19):2005-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Amory
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin.
Kanatsu-Shinohara M, Takehashi M, …, Fässler R, Shinohara T
Cell Stem Cell 2008 Nov 6 3(5):533-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Erika Matunis
Evaluated 13 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
 Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia.
Alcaraz J, Xu R, …, Bustamante C, Bissell MJ
EMBO J 2008 Oct 9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Egelhoff
Evaluated 6 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells.
Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J
J Biol Chem 2008 Sep 5 283(36):24435-47 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Silvana Curci with Andrea Gerbino
Evaluated 30 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Disrupted secretory activation of the mammary gland after antenatal glucocorticoid treatment in sheep.
Henderson JJ, Hartmann PE, …, Doherty DA, Newnham JP
Reproduction 2008 Nov 136(5):649-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ray Rodgers
Evaluated 27 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
 Association between 5-alpha reductase inhibition and risk of hip fracture.
Jacobsen SJ, Cheetham TC, …, Shi JM, Loo RK
JAMA 2008 Oct 8 300(14):1660-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Amory
Evaluated 24 Oct 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Generation of pluripotent stem cells from adult human testis.
Conrad S, Renninger M, …, Stenzl A, Skutella T
Nature 2008 Oct 8 [abstract on PubMed] [related articles] [full text]
Selected by | Ray Rodgers
Evaluated 22 Oct 2008


Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
 Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5.
Ng RK, Dean W, …, Reik W, Hemberger M
Nat Cell Biol 2008 Oct 5 [abstract on PubMed] [related articles] [full text]
Selected by | Christopher Ormandy with Heather Lee
Evaluated 21 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Title: Glucose Replacement to Euglycemia Causes Hypoxia, Acidosis, and Decreased Insulin Secretion in Fetal Sheep with Intrauterine Growth Restriction.
Rozance PJ, Limesand SW, …, Brown LD, Hay WW
Pediatr Res 2008 Aug 13 [abstract on PubMed] [related articles] [full text]
Selected by | Nick Illsley
Evaluated 20 Oct 2008


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