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Browse > Physiology > Cardiovascular Physiology/Circulation
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F1000 Factor 3.0

Hypothesis
New Finding
 Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.
Yago T, Lou J, …, McEver RP, Zhu C
J Clin Invest 2008 Sep 118(9):3195-207 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Xiaoping Du
Evaluated 20 Nov 2008

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F1000 Factor 3.0

New Finding
Novel Drug Target
 The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis.
Sapieha P, Sirinyan M, …, Sennlaub F, Chemtob S
Nat Med 2008 Oct 14(10):1067-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Raymond Harris
Evaluated 17 Nov 2008

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F1000 Factor 3.0

New Finding
 Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure.
Watanabe T, Takeda T, …, Shirasawa T, Otsu K
J Am Coll Cardiol 2008 Aug 26 52(9):779-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Frenneaux with Julian O M Ormerod
Evaluated 12 Nov 2008

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F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.
Chen CH, Budas GR, …, Hurley TD, Mochly-Rosen D
Science 2008 Sep 12 321(5895):1493-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 11 Nov 2008

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F1000 Factor 3.0

New Finding
 Rescue of volume-regulated anion current by bestrophin mutants with altered charge selectivity.
Chien LT, Hartzell HC
J Gen Physiol 2008 Nov 132(5):537-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bernd Nilius
Evaluated 10 Nov 2008

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F1000 Factor 6.0

New Finding
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 Sox18 induces development of the lymphatic vasculature in mice.
François M, Caprini A, …, Dejana E, Koopman P
Nature 2008 Oct 19 [abstract on PubMed] [related articles] [full text]
Selected by | Friedemann Kiefer
Evaluated 5 Nov 2008

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F1000 Factor 6.0

New Finding
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 Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.
Sale H, Wang J, …, Ackerman MJ, Robertson GA
Circ Res 2008 Sep 26 103(7):e81-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stanley Nattel
Evaluated 5 Nov 2008

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New Finding
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 ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
Noma K, Rikitake Y, …, Sun J, Liao JK
J Clin Invest 2008 May 118(5):1632-44 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ivan McMurtry
Evaluated 3 Nov 2008

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F1000 Factor 3.0

Controversial
Refutation
 Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis.
Serwold T, Ehrlich LI, Weissman IL
Blood 2008 Oct 16 [abstract on PubMed] [related articles] [full text]
Selected by | Hans-Reimer Rodewald
Evaluated 31 Oct 2008

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F1000 Factor 6.0

New Finding
Tech Advance
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 Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention.
Ge Y, Bagnall AJ, …, Kotelevtsev YV, Kohan DE
Am J Physiol Renal Physiol 2008 Sep 10 [abstract on PubMed] [related articles] [full text]
Selected by | David Pollock
Evaluated 31 Oct 2008


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