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Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine.
Lee S, Bowman BR, …, Wang S, Verdine GL
J Am Chem Soc 2008 Sep 3 130(35):11570-1 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Woski
Evaluated 3 Nov 2008

Recommended
F1000 Factor 3.0

Tech Advance
 In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy.
Cellitti SE, Jones DH, …, Schultz PG, Geierstanger BH
J Am Chem Soc 2008 Jul 23 130(29):9268-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gottfried Otting
Evaluated 3 Nov 2008

Exceptional
F1000 Factor 9.8

Hypothesis
New Finding
Tech Advance
 Structure of a complex of the ATPase SecA and the protein-translocation channel.
Zimmer J, Nam Y, Rapoport TA
Nature 2008 Oct 16 455(7215):936-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Manfred Schliwa / Ian Collinson / Art Horwich
Evaluated 31 Oct 2008

Exceptional
F1000 Factor 9.0

New Finding
 Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter.
Weyand S, Shimamura T, …, Henderson PJ, Cameron AD
Science 2008 Oct 16 [abstract on PubMed] [related articles] [full text]
Selected by | Ernest Wright
Evaluated 30 Oct 2008

Exceptional
F1000 Factor 9.0

Tech Advance
 Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules.
Hodis E, Prilusky J, …, Moult J, Sussman JL
Genome Biol 2008 Aug 3 9(8):R121 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Burkhard Rost
Evaluated 29 Oct 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Exalign: a new method for comparative analysis of exon-intron gene structures.
Pavesi G, Zambelli F, Caggese C, Pesole G
Nucleic Acids Res 2008 May 36:e47 [full text]
Selected by | Andras Fiser
Evaluated 28 Oct 2008

Recommended
F1000 Factor 3.0

Tech Advance
 The complete VS ribozyme in solution studied by small-angle X-ray scattering.
Lipfert J, Ouellet J, …, Doniach S, Lilley DM
Structure 2008 Sep 10 16(9):1357-67 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tamar Schlick with Christian Laing
Evaluated 28 Oct 2008

Must Read
F1000 Factor 4.8

Hypothesis
New Finding
Tech Advance
Controversial
 Remeasuring the double helix.
Mathew-Fenn RS, Das R, Harbury PA
Science 2008 Oct 17 322(5900):446-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | P. Shing Ho / Jim Maher
First evaluation 28 Oct 2008 | Latest evaluation 5 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
Tech Advance
 Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.
Zhang MQ, Gaisser S, …, Wilkinson B, Martin CJ
J Med Chem 2008 Sep 25 51(18):5494-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 27 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Concurrence of Danish dementia and cataract: insights from the interactions of dementia associated peptides with eye lens alpha-crystallin.
Surolia I, Sinha S, …, Reddy GB, Surolia A
PLoS ONE 2008 3(8):e2927 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Narayanaswamy Srinivasan
Evaluated 24 Oct 2008


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