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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Actin dynamics is essential for myosin-based transport of membrane organelles.
Semenova I, Burakov A, …, Kashina A, Rodionov V
Curr Biol 2008 Oct 28 18(20):1581-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anna Akhmanova
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
Refutation
Novel Drug Target
 Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.
Baxter NJ, Blackburn GM, …, Wemmer DE, Waltho JP
J Am Chem Soc 2008 Mar 26 130(12):3952-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arieh Warshel with Shina Caroline Lynn Kamerlin
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7.
Rojas R, van Vlijmen T, …, van der Sluijs P, Bonifacino JS
J Cell Biol 2008 Nov 3 183(3):513-26 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Roth
Evaluated 12 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.
Sheaffer KL, Updike DL, Mango SE
Curr Biol 2008 Sep 23 18(18):1355-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher Proud
Evaluated 12 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Ordered assembly of the ESCRT-III complex on endosomes is required to sequester cargo during MVB formation.
Teis D, Saksena S, Emr SD
Dev Cell 2008 Oct 15(4):578-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tom Stevens with Emily M. Coonrod
Evaluated 10 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1.
Nikko E, Sullivan JA, Pelham HR
EMBO Rep 2008 Oct 24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sharad Kumar
Evaluated 7 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.
Gack MU, Kirchhofer A, …, Hopfner KP, Jung JU
Proc Natl Acad Sci U S A 2008 Oct 28 105(43):16743-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Gale
Evaluated 5 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 The effect of cholesterol on short- and long-chain monounsaturated lipid bilayers as determined by molecular dynamics simulations and X-ray scattering.
Kucerka N, Perlmutter JD, …, Katsaras J, Sachs JN
Biophys J 2008 Sep 15 95(6):2792-805 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nathan Baker with Brett Olsen
Evaluated 4 Nov 2008

Exceptional
F1000 Factor 9.9

Hypothesis
New Finding
 Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity.
Wang Z, Edwards JG, …, Kauer JA, Ehlers MD
Cell 2008 Oct 31 135(3):535-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Timothy Ryan / Volker Haucke / Jonathan Flint with Thomas Campbell
First evaluation 4 Nov 2008 | Latest evaluation 11 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Herpes Simplex Virus 1 Protein Kinase Us3 Phosphorylates Viral Envelope Glycoprotein B and Regulates Its Expression on the Cell Surface.
Kato A, Arii J, …, Arase H, Kawaguchi Y
J Virol 2008 Oct 22 [abstract on PubMed] [related articles] [full text]
Selected by | Rozanne Sandri-Goldin
Evaluated 3 Nov 2008


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