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Must Read
F1000 Factor 6.0

New Finding
 Identification of a motif in the acetylcholine receptor beta subunit whose phosphorylation regulates rapsyn association and postsynaptic receptor localization.
Borges LS, Yechikhov S, …, Burden SJ, Ferns MJ
J Neurosci 2008 Nov 5 28(45):11468-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | H. Benjamin Peng with Raghavan Madhavan
Evaluated 28 Nov 2008

Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
 Deconstructing voltage sensor function and pharmacology in sodium channels.
Bosmans F, Martin-Eauclaire MF, Swartz KJ
Nature 2008 Nov 13 456(7219):202-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 26 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 The Arg-Gly-Asp-containing, solvent-exposed loop of Ptr ToxA is required for internalization.
Manning VA, Hamilton SM, Karplus PA, Ciuffetti LM
Mol Plant Microbe Interact 2008 Mar 21(3):315-25 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Ebbole
Evaluated 25 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3varepsilon Cytoplasmic Tyrosine-Based Motif.
Xu C, Gagnon E, …, Chou JJ, Wucherpfennig KW
Cell 2008 Nov 14 135(4):702-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Brigitte Huber
Evaluated 24 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Genome-wide screen of Saccharomyces cerevisiae null allele strains identifies genes involved in selenomethionine resistance.
Bockhorn J, Balar B, …, Copeland PR, Kinzy TG
Proc Natl Acad Sci U S A 2008 Nov 11 [abstract on PubMed] [related articles] [full text]
Selected by | Ann Stock
Evaluated 21 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
 {alpha}- and {beta}- Monosaccharide Transport in Human Erythrocytes.
Carruthers A, Leitch J
Am J Physiol Cell Physiol 2008 Nov 5 [abstract on PubMed] [related articles] [full text]
Selected by | Richard J Naftalin
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Tech Advance
Novel Drug Target
 Generating Arrays with High Content and Minimal Consumption of Functional Membrane Proteins.
Majd S, Mayer M
J Am Chem Soc 2008 Nov 1 0 [abstract on PubMed] [related articles] [full text]
Selected by | Ross Weatherman
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Agonist-selective, Receptor-specific Interaction of Human P2Y Receptors with {beta}-Arrestin-1 and -2.
Hoffmann C, Ziegler N, …, Krasel C, Lohse MJ
J Biol Chem 2008 Nov 7 283(45):30933-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ralf Jockers with Maud Kamal
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Importance of Direct Interactions with Lipids for the Function of the Mechanosensitive Channel MscL.
Powl AM, East JM, Lee AG
Biochemistry 2008 Oct 25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ian Booth
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 A Novel Class of Modular Transporters for Vitamins in Prokaryotes.
Rodionov DA, Hebbeln P, …, Hanson AD, Eitinger T
J Bacteriol 2008 Oct 17 [abstract on PubMed] [related articles] [full text]
Selected by | Hanjo Hellmann
Evaluated 12 Nov 2008


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