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F1000 Factor 3.0

New Finding
Tech Advance
 Alternative isoform regulation in human tissue transcriptomes.
Wang ET, Sandberg R, …, Schroth GP, Burge CB
Nature 2008 Nov 2 [abstract on PubMed] [related articles] [full text]
Selected by | Ken Irvine with Yongqiang Feng
Evaluated 20 Nov 2008

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F1000 Factor 6.0

Hypothesis
New Finding
 Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs.
Hirota K, Miyoshi T, …, Shibata T, Ohta K
Nature 2008 Nov 6 456(7218):130-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 18 Nov 2008

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F1000 Factor 3.0

New Finding
Controversial
 The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster.
Tucker NP, Hicks MG, …, Dixon R, Hutchings MI
PLoS ONE 2008 3(11):e3623 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Spiro
Evaluated 18 Nov 2008

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F1000 Factor 3.0

Hypothesis
New Finding
Controversial
 Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation.
Vitaliano-Prunier A, Menant A, …, Gwizdek C, Dargemont C
Nat Cell Biol 2008 Nov 10(11):1365-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bernhard Dichtl with André Halbach
Evaluated 17 Nov 2008

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F1000 Factor 6.0

Hypothesis
New Finding
 Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome.
Zhao J, Sun BK, …, Song JJ, Lee JT
Science 2008 Oct 31 322(5902):750-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Brad Bernstein
Evaluated 17 Nov 2008

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F1000 Factor 3.0

New Finding
 Splicing factors facilitate RNAi-directed silencing in fission yeast.
Bayne EH, Portoso M, …, Rappsilber J, Allshire RC
Science 2008 Oct 24 322(5901):602-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Craig Pikaard
Evaluated 13 Nov 2008

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F1000 Factor 6.6

Hypothesis
New Finding
 HARP is an ATP-driven annealing helicase.
Yusufzai T, Kadonaga JT
Science 2008 Oct 31 322(5902):748-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Botchan / Lucio Comai / Jessica Downs
First evaluation 13 Nov 2008 | Latest evaluation 17 Nov 2008

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F1000 Factor 3.0

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 The SIRT2 Deacetylase Regulates Autoacetylation of p300.
Black JC, Mosley A, …, Washburn M, Carey M
Mol Cell 2008 Nov 7 32(3):449-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Cheng-Ming Chiang
Evaluated 12 Nov 2008

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F1000 Factor 3.0

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 Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways.
Kwapisz M, Wery M, …, Thuriaux P, Lacroute F
EMBO J 2008 Sep 17 27(18):2411-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jesper Svejstrup with Ozan Aygun
Evaluated 11 Nov 2008

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F1000 Factor 3.0

Confirmation
 Site-specific cross-linking of TBP in vivo and in vitro reveals a direct functional interaction with the SAGA subunit Spt3.
Mohibullah N, Hahn S
Genes Dev 2008 Nov 1 22(21):2994-3006 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tony Weil
Evaluated 11 Nov 2008


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