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Recommended
F1000 Factor 3.0

New Finding
Murine IL-4 is able to signal via chimeric human IL-4Ralpha/mouse gamma-chain receptor.
Myburgh E, Horsnell WG, …, Kubo M, Brombacher F
Mol Immunol 2008 Mar 45(5):1327-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Achsah Keegan with Nicola M. Heller
Evaluated 5 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Controversial
Parasites prevent summer breeding in white-footed mice, Peromyscus leucopus.
Vandegrift KJ, Raffel TR, Hudson PJ
Ecology 2008 89:2251-2258 [full text]
Selected by | M. Denise Dearing
Evaluated 5 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses.
Hall JA, Bouladoux N, …, Berzofsky JA, Belkaid Y
Immunity 2008 Oct 1 [abstract on PubMed] [related articles] [full text]
Selected by | Padmini Salgame with Amanda McBride
Evaluated 29 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Novel Drug Target
Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine?
Wilson RA, Langermans JA, …, Thomas AW, Coulson PS
PLoS Negl Trop Dis 2008 2(9):e290 [abstract on PubMed] [related articles] [FREE full text]
Selected by | W. Evan Secor
Evaluated 29 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites.
Bozdech Z, Mok S, …, Carlton JM, Preiser PR
Proc Natl Acad Sci U S A 2008 Oct 21 105(42):16290-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Roepe
Evaluated 29 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Role of protein translocation pathways across the ER in trypanosoma brucei.
Goldshmidt H, Sheiner L, …, Engstler M, Michaeli S
J Biol Chem 2008 Sep 2 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Karin Romisch
Evaluated 28 Oct 2008

Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
A new class of anthelmintics effective against drug-resistant nematodes.
Kaminsky R, Ducray P, …, Sluder A, Maser P
Nature 2008 Mar 13 452(7184):176-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | R. Kip Guy
Evaluated 24 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii.
Hunn JP, Koenen-Waisman S, …, Martens S, Howard JC
EMBO J 2008 Oct 8 27(19):2495-509 [abstract on PubMed] [related articles] [FREE full text]
Selected by | L. David Sibley
Evaluated 22 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Comparative genomics of the neglected human malaria parasite Plasmodium vivax.
Carlton JM, Adams JH, …, Barnwell JW, Fraser-Liggett CM
Nature 2008 Oct 9 455(7214):757-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Seeber
Evaluated 21 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model.
Abdulla MH, O'Brien T, …, Grab DJ, McKerrow JH
PLoS Negl Trop Dis 2008 2(9):e298 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Mansfield
Evaluated 20 Oct 2008


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