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Recommended
F1000 Factor 3.0

Hypothesis
 Stimulation of Ebola virus production from persistent infection through activation of the Ras/MAPK pathway.
Strong JE, Wong G, …, Kobinger GP, Feldmann H
Proc Natl Acad Sci U S A 2008 Nov 3 105 [abstract on PubMed] [related articles] [full text]
Selected by | Kanta Subbarao with Catherine Luke
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
 Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands.
Kvansakul M, Yang H, …, Huang DC, Colman PM
Cell Death Differ 2008 Oct 15(10):1564-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Andrews
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Controversial
 The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster.
Tucker NP, Hicks MG, …, Dixon R, Hutchings MI
PLoS ONE 2008 3(11):e3623 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Spiro
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Bacterial biosynthesis of a multipotent stilbene.
Joyce SA, Brachmann AO, …, Clarke DJ, Bode HB
Angew Chem Int Ed Engl 2008 47(10):1942-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barrie Wilkinson
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus.
Bornholdt ZA, Prasad BV
Nature 2008 Nov 5 [abstract on PubMed] [related articles] [full text]
Selected by | Samuel Butcher
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Substituted 2-Imino-5-arylidenethiazolidin-4-one Inhibitors of Bacterial Type III Secretion.
Kline T, Felise HB, …, Nguyen HV, Miller SI
J Med Chem 2008 Oct 24 0 [abstract on PubMed] [related articles] [full text]
Selected by | Robert Fecik
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.2

New Finding
Tech Advance
Novel Drug Target
 Engineering microRNA responsiveness to decrease virus pathogenicity.
Kelly EJ, Hadac EM, Greiner S, Russell SJ
Nat Med 2008 Nov 14(11):1278-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Crowe / Lynne Maquat with Olaf Isken
First evaluation 12 Nov 2008 | Latest evaluation 19 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Substrains of 129 mice are resistant to Yersinia pestis KIM5: Implications for IL-10 deficient mice.
Turner JK, Xu JL, Tapping RI
Infect Immun 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | James Bliska
Evaluated 11 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo.
Bischof LJ, Kao CY, …, van der Goot FG, Aroian RV
PLoS Pathog 2008 Oct 4(10):e1000176 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Guy Tran Van Nhieu
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Pseudomonas aeruginosa induces localized immunosuppression during pneumonia.
Diaz MH, Shaver CM, …, Kazzaz JA, Hauser AR
Infect Immun 2008 Oct 76(10):4414-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joanna Goldberg
Evaluated 7 Nov 2008


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