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Recommended
F1000 Factor 3.0

Hypothesis
Reconstruction of the genome origins and evolution of the hybrid lager yeast Saccharomyces pastorianus.
Dunn B, Sherlock G
Genome Res 2008 Oct 18(10):1610-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Audrey Gasch
Evaluated 20 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Sequential asymmetric polyketide heterocyclization catalyzed by a single cytochrome P450 monooxygenase (AurH).
Richter ME, Traitcheva N, Knüpfer U, Hertweck C
Angew Chem Int Ed Engl 2008 47(46):8872-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 7 Nov 2008

Recommended
F1000 Factor 3.0

Tech Advance
Detection, localization, and conformational analysis of single polysaccharide molecules on live bacteria.
Francius G, Lebeer S, …, Vanderleyden J, Dufrene Y
ACS Nano 2008 2 [full text]
Selected by | Robert Palmer
Evaluated 5 Nov 2008

Must Read
F1000 Factor 4.8

New Finding
Tech Advance
Extreme substrate promiscuity of the Neisseria oligosaccharyltransferase involved in protein O-glycosylation.
Faridmoayer A, Fentabil MA, …, Wang PG, Feldman MF
J Biol Chem 2008 Oct 17 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Miguel Valvano / Barbara Imperiali
First evaluation 30 Oct 2008 | Latest evaluation 19 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
Tech Advance
Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.
Zhang MQ, Gaisser S, …, Wilkinson B, Martin CJ
J Med Chem 2008 Sep 25 51(18):5494-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Wipf
Evaluated 27 Oct 2008

Recommended
F1000 Factor 3.2

Hypothesis
New Finding
Novel Drug Target
Bacterial protection of beetle-fungus mutualism.
Scott JJ, Oh DC, …, Clardy J, Currie CR
Science 2008 Oct 3 322(5898):63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Keith Chater / Joe Heitman with Yen-Ping Hsueh
Evaluated 24 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins.
Zhao P, Bai L, …, Deng Z, Floss HG
Chem Biol 2008 Aug 25 15(8):863-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson with Gavin J. Williams
Evaluated 23 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits.
Brandl K, Plitas G, …, DeMatteo RP, Pamer EG
Nature 2008 Oct 9 455(7214):804-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Lecuit
Evaluated 22 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
Novel Drug Target
Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.
Ericson E, Gebbia M, …, Giaever G, Nislow C
PLoS Genet 2008 4(8):e1000151 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ramon Serrano
Evaluated 20 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
Bioencapsulation of living bacteria (Escherichia coli) with poly(silicate) after transformation with silicatein-alpha gene.
Müller WE, Engel S, …, Divekar M, Schröder HC
Biomaterials 2008 Mar 29(7):771-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Russell Hill
Evaluated 9 Oct 2008


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