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Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.
Jackson NE, Wang HW, …, Cairns J, Hunt JE
J Biol Chem 2008 Oct 14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard L. Stevens
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1-family member IL-33.
Pecaric-Petkovic T, Didichenko SA, …, Spiegl N, Dahinden CA
Blood 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Marc Rothenberg with Ariel Munitz
Evaluated 13 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Controversial
IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma.
Song C, Luo L, …, Huang B, Feng ZH
J Immunol 2008 Nov 1 181(9):6117-24 [abstract on PubMed] [related articles] [order article]
Selected by | Dan Conrad
Evaluated 11 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Murine IL-4 is able to signal via chimeric human IL-4Ralpha/mouse gamma-chain receptor.
Myburgh E, Horsnell WG, …, Kubo M, Brombacher F
Mol Immunol 2008 Mar 45(5):1327-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Achsah Keegan with Nicola M. Heller
Evaluated 5 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
McKinley L, Alcorn JF, …, Ray A, Kolls JK
J Immunol 2008 Sep 15 181(6):4089-97 [abstract on PubMed] [related articles] [order article]
Selected by | Dan Conrad
Evaluated 31 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung.
Taranova AG, Maldonado D, …, Lee NA, Lee JJ
Cancer Res 2008 Oct 15 68(20):8582-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Helene Rosenberg
Evaluated 29 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Akiyama T, Shimo Y, …, Takahama Y, Inoue J
Immunity 2008 Sep 29(3):423-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Anderson with Jason Devoss
Evaluated 24 Oct 2008

Must Read
F1000 Factor 4.8

New Finding
Novel Drug Target
Plasmacytoid dendritic cells mediate oral tolerance.
Goubier A, Dubois B, …, Trinchieri G, Kaiserlian D
Immunity 2008 Sep 29(3):464-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Luciano Adorini / Maria Rescigno
First evaluation 23 Oct 2008 | Latest evaluation 24 Oct 2008

Must Read
F1000 Factor 6.5

New Finding
Novel Drug Target
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.
Cisse B, Caton ML, …, Zhuang Y, Reizis B
Cell 2008 Oct 3 135(1):37-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Brigitte Huber / Marco Colonna / David Allman with Benjamin Harman
First evaluation 22 Oct 2008 | Latest evaluation 31 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages.
Goleva E, Hauk PJ, …, Martin RJ, Leung DY
J Allergy Clin Immunol 2008 Sep 122(3):550-9.e3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lanny Rosenwasser
Evaluated 21 Oct 2008



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