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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
Yano M, Kuroda N, …, Mouri Y, Matsumoto M
J Exp Med 2008 Nov 17 [abstract on PubMed] [related articles] [full text]
Selected by | David Chaplin
Evaluated 19 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming.
Martín-Fontecha A, Baumjohann D, …, Lanzavecchia A, Sallusto F
J Exp Med 2008 Oct 27 205(11):2561-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Bradley
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells.
Schneider A, Rieck M, …, Greenbaum C, Buckner JH
J Immunol 2008 Nov 15 181(10):7350-5 [abstract on PubMed] [related articles] [order article]
Selected by | Matthias von Herrath with Christophe Filippi
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Disruption of neurofascin and gliomedin at nodes of Ranvier precedes demyelination in experimental allergic neuritis.
Lonigro A, Devaux JJ
Brain 2008 Oct 25 [abstract on PubMed] [related articles] [full text]
Selected by | Elior Peles
Evaluated 11 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Pesu M, Watford WT, …, Creemers J, O'Shea JJ
Nature 2008 Sep 11 455(7210):246-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Fuller
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.
Koulmanda M, Bhasin M, …, Flier JS, Strom TB
Proc Natl Acad Sci U S A 2008 Oct 21 105(42):16242-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Atkinson
Evaluated 4 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene.
Juran BD, Atkinson EJ, …, Fridley BL, Lazaridis KN
Gastroenterology 2008 Oct 135(4):1200-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 3 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 The innate NK cells, allograft rejection, and a key role for IL-15.
Kroemer A, Xiao X, …, Demirci G, Li XC
J Immunol 2008 Jun 15 180(12):7818-26 [abstract on PubMed] [related articles] [order article]
Selected by | Gerald Spangrude
Evaluated 29 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function.
Ewaschuk JB, Diaz H, …, Looijer-van Langen M, Madsen KL
Am J Physiol Gastrointest Liver Physiol 2008 Sep 11 [abstract on PubMed] [related articles] [full text]
Selected by | Helen Raybould
Evaluated 29 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease.
Zhu B, Symonds AL, …, Li S, Wang P
J Exp Med 2008 Sep 29 205(10):2295-307 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Laurence Morel
Evaluated 27 Oct 2008


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