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Browse > Immunology > Immune Response
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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
Yano M, Kuroda N, …, Mouri Y, Matsumoto M
J Exp Med 2008 Nov 17 [abstract on PubMed] [related articles] [full text]
Selected by | David Chaplin
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I IFN, and immune suppression.
Malleret B, Maneglier B, …, Le Grand R, Vaslin B
Blood 2008 Sep 11 [abstract on PubMed] [related articles] [full text]
Selected by | Gene Shearer with Adriano Boasso
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Memory CD8 T-cell compartment grows in size with immunological experience.
Vezys V, Yates A, …, Antia R, Masopust D
Nature 2008 Nov 12 [abstract on PubMed] [related articles] [full text]
Selected by | Barry Rouse
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming.
Martín-Fontecha A, Baumjohann D, …, Lanzavecchia A, Sallusto F
J Exp Med 2008 Oct 27 205(11):2561-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Bradley
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells.
Schneider A, Rieck M, …, Greenbaum C, Buckner JH
J Immunol 2008 Nov 15 181(10):7350-5 [abstract on PubMed] [related articles] [order article]
Selected by | Matthias von Herrath with Christophe Filippi
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Human basophils and eosinophils are the direct target leukocytes of the novel IL-1-family member IL-33.
Pecaric-Petkovic T, Didichenko SA, …, Spiegl N, Dahinden CA
Blood 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Marc Rothenberg with Ariel Munitz
Evaluated 13 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Triggering the succinate receptor GPR91 on dendritic cells enhances immunity.
Rubic T, Lametschwandtner G, …, Rot A, Carballido JM
Nat Immunol 2008 Nov 9(11):1261-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mauro Teixeira
Evaluated 10 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity.
Cella M, Fuchs A, …, Mills JC, Colonna M
Nature 2008 Nov 2 [abstract on PubMed] [related articles] [full text]
Selected by | Mauro Teixeira
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 EsaC substrate for the ESAT-6 secretion pathway and its role in persistent infections of Staphylococcus aureus.
Burts ML, DeDent AC, Missiakas DM
Mol Microbiol 2008 Aug 69(3):736-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rino Rappuoli with Fabio Bagnoli
Evaluated 5 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death.
Chen M, Divangahi M, …, Behar SM, Remold HG
J Exp Med 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Andrea Cooper
Evaluated 4 Nov 2008


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