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F1000 Factor 3.0

New Finding
Structure of IL-22 bound to its high-affinity IL-22R1 chain.
Jones BC, Logsdon NJ, Walter MR
Structure 2008 Sep 10 16(9):1333-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gideon Schreiber
Evaluated 20 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
Yano M, Kuroda N, …, Mouri Y, Matsumoto M
J Exp Med 2008 Nov 17 [abstract on PubMed] [related articles] [full text]
Selected by | David Chaplin
Evaluated 19 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines.
Anagnostou SH, Shepherd PR
Biochem J 2008 Dec 1 416(2):211-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alex Toker
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.
Suzuki T, Sakagami T, …, van der Loo JC, Trapnell BC
J Exp Med 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Glenn Dranoff
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming.
Martín-Fontecha A, Baumjohann D, …, Lanzavecchia A, Sallusto F
J Exp Med 2008 Oct 27 205(11):2561-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Bradley
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.
Jackson NE, Wang HW, …, Cairns J, Hunt JE
J Biol Chem 2008 Oct 14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard L. Stevens
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1-family member IL-33.
Pecaric-Petkovic T, Didichenko SA, …, Spiegl N, Dahinden CA
Blood 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Marc Rothenberg with Ariel Munitz
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Substrains of 129 mice are resistant to Yersinia pestis KIM5: Implications for IL-10 deficient mice.
Turner JK, Xu JL, Tapping RI
Infect Immun 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | James Bliska
Evaluated 11 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Controversial
IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma.
Song C, Luo L, …, Huang B, Feng ZH
J Immunol 2008 Nov 1 181(9):6117-24 [abstract on PubMed] [related articles] [order article]
Selected by | Dan Conrad
Evaluated 11 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Tech Advance
Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold.
Heidema J, Rossen JW, …, Kimpen JL, van Bleek GM
J Immunol 2008 Oct 15 181(8):5551-9 [abstract on PubMed] [related articles] [order article]
Selected by | Peter Openshaw
Evaluated 10 Nov 2008


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